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Full-Text Articles in Microbiology
Is The Ubiquitous Antibacterial Agent Triclosan An Uncoupler Of Mammalian Mitochondria, Hina Hashmi
Is The Ubiquitous Antibacterial Agent Triclosan An Uncoupler Of Mammalian Mitochondria, Hina Hashmi
Honors College
Triclosan (TCS), an antibacterial agent widely found in household and clinical products, is readily absorbed into human skin, but TCS effects on mammalian cells are largely unknown. TCS has been found to alleviate symptoms of human eczema, via an unknown mechanism. Mast cells are ubiquitous, key players in allergy, infectious disease, carcinogenesis, autism, and many other diseases and physiological functions. One important function of mast cells is release of pro-inflammatory mediators from intracellular granules (degranulation) upon challenge with antigen. Non-cytotoxic doses of TCS inhibit several functions of both human (HMC-1.2) and rat (RBL-2H3) mast cells, including degranulation. Previous work in …
Urbanization Changes The Composition And Bioavailability Of Dissolved Organic Matter In Headwater Streams, Thomas B. Parr, Christopher Cronan, Tsutomu Ohno, Stuart Findlay, Sean Smith, Kevin Simon
Urbanization Changes The Composition And Bioavailability Of Dissolved Organic Matter In Headwater Streams, Thomas B. Parr, Christopher Cronan, Tsutomu Ohno, Stuart Findlay, Sean Smith, Kevin Simon
Publications
Population growth in cities has resulted in the rapid expansion of urbanized land. Most research and management of stream ecosystems affected by urban expansion has focused on the maintenance and restoration of biotic communities rather than their basal resources. We examined the potential for urbanization to induce bottom-up ecosystem effects by looking at its influence on dissolved organic matter (DOM) composition and bioavailability and microbial enzyme activity. We selected 113 headwater streams across a gradient of urbanization in central and southern Maine and used elemental and optical analyses, including parallel factor analysis of excitation-emission matrices, to characterize DOM composition. Results …