Marine Biology Commons^™

Environmental Pseudomonads Inhibit Cystic Fibrosis Patient-Derived Pseudomonas Aeruginosa, Payel Chatterjee, Elizabeth Davis, Fengan Yu, Sarah James, Julia H. Wildschutte, Daniel D. Wiegmann, David H. Sherman, Robert M. Mckay, John J. Lipuma, Hans Wildschutte

Great Lakes Institute for Environmental Research Publications

Pseudomonas aeruginosa is an opportunistic pathogen which is evolving resistance to many currently used antibiotics. While much research has been devoted to the roles of pathogenic P. aeruginosa in cystic fibrosis (CF) patients, less is known of its ecological properties. P. aeruginosa dominates the lungs during chronic infection in CF patients, yet its abundance in some environments is less than that of other diverse groups of pseudomonads. Here, we sought to determine if clinical isolates of P. aeruginosa are vulnerable to environmental pseudomonads that dominate soil and water habitats in one-to-one competitions which may provide a source of inhibitory factors. …