Biomechanics Commons^™

The Impact Of Combined Flexion And Compression On The Mechanical Integrity Of The Annulus Fibrosus, Keaton Briar

Theses and Dissertations (Comprehensive)

Introduction: Intervertebral disc (IVD) herniation is characterized by an expulsion of nucleus pulposus (NP) material through the annulus fibrosus (AF). The AF contains two major adhesive structures, the intralamellar matrix and the interlamellar matrix, which act to maintain the strength of the AF and prevent NP material migration. As a herniation occurs, clefts form within the intralamellar matrix, pushing the NP between adjacent collagen fibres; meanwhile, delamination of the interlamellar matrix causes the NP to pool between layers of the AF. Further, herniation more readily occurs in a combined loading scenario of both compression and flexion. Flexion, and in particular …

Toll-Like Receptor 4 Inhibition Differentially Impacts Intervertebral Disc Axial Mechanics In Wild Type And Sparc-Null Mice, Mitch Whittal

Theses and Dissertations (Comprehensive)

Study Design. In vivo examination of the influence of TAK-242 (resatorvid) treatment on the mechanical properties of the intervertebral disc (IVD) in secreted protein acidic and rich in cysteine (SPARC) gene knockout (SPARC-null) mice.

Objectives. To examine if chronic TAK-242 treatment mitigates mechanical degradation associated with IVD degeneration in SPARC-null mice.

Summary of Background data. IVD degeneration is associated with low back pain (LBP) and is accompanied by mechanical changes to the spine. SPARC is a protein that contributes to the functioning and maintenance of the extracellular matrix (ECM), with SPARC-null mice displaying accelerated IVD degeneration. TAK-242 is a toll-like …