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Full-Text Articles in Biomechanics
An Investigation Of The Relationship Between Intervertebral Disc Puncture, Inflammation, And Tissue Mechanics Using A Rat-Tail Model., Brigitte Laird
An Investigation Of The Relationship Between Intervertebral Disc Puncture, Inflammation, And Tissue Mechanics Using A Rat-Tail Model., Brigitte Laird
Theses and Dissertations (Comprehensive)
Introduction: The intervertebral disc (IVD) is composed of the annulus fibrosus (AF), which surrounds and contains the nucleus pulposus (NP). It is hypothesized that when the IVD becomes injured, in the case of IVD herniation, a localized innate immune response is initiated. Although the presence of pro-inflammatory cytokines in injured IVDs has been well documented, the extent to which inflammation affects the mechanical properties of the IVD remains poorly understood. The purpose of this study was to determine the effect of IVD damage (via puncture) and inflammation (via lipopolysaccharide (LPS) exposure) on the mechanical and structural properties of the IVD. …