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Articles 1 - 4 of 4
Full-Text Articles in Biomechanics
Obstacle Crossing In Healthy Young And Older Individuals, Hope M. Hanson, Ashlyn M. Jendro, Abigail C. Schmitt
Obstacle Crossing In Healthy Young And Older Individuals, Hope M. Hanson, Ashlyn M. Jendro, Abigail C. Schmitt
Health, Human Performance and Recreation Undergraduate Honors Theses
Introduction: In the United States, the average population age is rising and will continue to increase in the coming years.With an older population comes increased risk of injury associated with falls. Falls are considered a leading cause of injury and death in older individuals, and many falls are caused by body imbalance or obstacle collision due to a clearly visible stationary object (e.g., rug, chair, branch). Older adults tend to cross obstacles with increased toe clearance in order to prevent tripping, but much of what is known about obstacle crossing in older adults is limited to artificial obstacles that are …
Sex Differences In Cancer Cachexia And A Novel Mitochondrial Target For Cancer-Induced Muscle Wasting, Seongkyun Lim
Sex Differences In Cancer Cachexia And A Novel Mitochondrial Target For Cancer-Induced Muscle Wasting, Seongkyun Lim
Graduate Theses and Dissertations
Cancer cachexia (CC) is a devastating wasting syndrome characterized by marked weight loss including skeletal muscle atrophy that affects approximately 80% of cancer patients. Current therapeutic treatments including pharmacological and nutritional intervention are insufficient to prevent or reverse it. Prior studies demonstrated lower muscle mass, impaired muscle function, and mitochondrial health in the development of CC. Specifically, mitochondrial fusion protein, Optic atrophy 1 (OPA1) which plays a significant role in skeletal muscle health, is suppressed in the development of CC. Furthermore, most pre-clinical CC studies were mainly focused on males although there are distinct phenotypical differences in skeletal muscle between …
The Role Of Protein Degradation In Cancer Cachexia In Female Tumor Bearing Mice, Noah Thomas
The Role Of Protein Degradation In Cancer Cachexia In Female Tumor Bearing Mice, Noah Thomas
Graduate Theses and Dissertations
Background: Cancer is a leading cause of death in the world in which half of the people affected by this disease die from its effects. Cancer-cachexia is a syndrome associated with the significant loss of skeletal muscle mass and function, which cannot be fully reversed by nutritional intervention alone and in turn, impairs the host. Cancer-cachexia affects 50-80% of cancer patients and is a primary cause of death accounting for 20-40% of cancer related deaths. Efforts to reverse the effects of cancer-related cachexia have been largely unsuccessful and have primarily focused on the late stages of CC. Methods: Lewis Lung …
Validity And Reliability Of A 5-Minute Web-Camera Based Eye Tracking Test To Assess Visual Memory And Cognition, Emily Bates
Validity And Reliability Of A 5-Minute Web-Camera Based Eye Tracking Test To Assess Visual Memory And Cognition, Emily Bates
Graduate Theses and Dissertations
There are approximately 5.7 million Americans currently living with Alzheimer’s Disease (AD). Early detection of cognitive impairment allows for earlier treatment, potentially slowing or halting cognitive decline. A 30-min web-camera eye tracking assessment (30-min VPC) has been validated as a tool to predict AD risk. However, a shorter version would allow for greater scalability and improve user experience. The purpose of this study was to: 1) determine the validity of the 5-minute web-camera based VPC test with the 30-min test, 2) determine the test-retest reliability of the 5-min test, 3) compare the 5-minute test scores of cognitively intact adults (18-39 …