Biomechanics Commons^™

An Investigation Of The Mechanism Of Traumatic Brain Injury Caused By Blast In The Open Field, Ke Feng

Wayne State University Dissertations

Blast-induced traumatic brain injury (bTBI) is a signature wound of modern warfare. The current incomplete understanding of its injury mechanism impedes the development of strategies for effective protection of bTBI. Despite a considerable amount of experimental animal studies focused on the evaluation of brain neurotrauma caused by blast exposure, there is very limited knowledge on the biomechanical responses of the gyrenecephalic brain subjected to primary free-field blast waves imposed in vivo, and the correlation analysis between the biomechanical responses and its injury outcomes. Such information is crucial to the development of injury criteria of bTBI.

This study aims to evaluate …

A Multi-Species Analysis Of Biomechanical Responses Of The Head To A Shock Wave, Richard Bolander

Wayne State University Dissertations

Shock wave induced brain injury remains a field of research that has great consequences for the rehabilitation of soldiers and civilians that are exposed to an explosion. As such, for the research to be successful in developing strategies to mitigate the effects of these injuries, appropriate research methods need to be developed. Animal models are currently employed to understand the brain's response to a shock wave exposure. Unfortunately no criteria have been established that indicates in what way the mechanical inputs that the cells in an animal's brain are subjected to are similar to a human. The purpose of this …