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Full-Text Articles in Kinesiology

Neural Activation In Blood-Flow-Restricted Versus Non-Blood-Flow-Restricted Exercise: An Fmri Study, Tiffany Dawn Devries May 2016

Neural Activation In Blood-Flow-Restricted Versus Non-Blood-Flow-Restricted Exercise: An Fmri Study, Tiffany Dawn Devries

Theses and Dissertations

Functional magnetic resonance imaging (fMRI) can be used to track neural activation in the brain during functional activities. The purpose of this study was to investigate brain neural responses to blood flow restricted (BFR) versus control handgrip exercise. Using a randomized crossover design, 25 subjects (12 males, 13 females) completed handgrip exercises during two conditions: BFR vs. control. To familiarize participants with the exercise conditions, one week prior to MRI scanning participants completed each exercise condition once on separate days, with 72 hours between days. The following week fMRI scans were performed at the same time of day, separated by …


Acute Changes In Running Mechanics Across Footwear With Various Heel-To-Toe Height Differences, Daniel C. Moody Mar 2016

Acute Changes In Running Mechanics Across Footwear With Various Heel-To-Toe Height Differences, Daniel C. Moody

Theses and Dissertations

There are many different types of footwear available for runners in today's market. Many of these shoes claim to improve a runner's efficiency by altering their stride mechanics. Minimalist footwear claims to aid runners in running more on their forefeet whereas more traditional footwear provides more cushioning specifically for a heel-first landing. The purpose of this research was to determine if runners who were accustomed to running in traditional footwear would acutely alter their running biomechanics when they ran barefoot or in various types of minimalist footwear. Twelve subjects, who were accustomed to running in traditional 12 mm heel/toe differential …


Neural Response To Food Cues After Moderate And Vigorous Exercise In Women: A Randomized Crossover Trial, Jillesa Anderson Mar 2016

Neural Response To Food Cues After Moderate And Vigorous Exercise In Women: A Randomized Crossover Trial, Jillesa Anderson

Theses and Dissertations

PURPOSE: This study examined the effect of different intensities of acute exercise on attention allocation to visual food cues, postexercise energy intake, and subjective measures of hunger in women. METHODS: This crossover study utilized treatment conditions that were randomized and counter-balanced. Fifty-two adult women, 18-29 years, were compared under three separate conditions: no exercise, 45 min of moderate-intensity exercise at 3.9 METs and 22.5 min of vigorous-intensity exercise at 7.8 METs. To measure attention allocation to visual food cues, participants were shown a passive viewing task consisting of a continual stream of pictures of food (high and low calorie) and …


The Effect Of Whole Body Vibration On Exercise-Induced Muscle Damage And Delayed-Onset Muscle Soreness, Ryan Darin Magoffin Mar 2016

The Effect Of Whole Body Vibration On Exercise-Induced Muscle Damage And Delayed-Onset Muscle Soreness, Ryan Darin Magoffin

Theses and Dissertations

Current scientific evidence suggests that when whole body vibration (WBV) is used as a warm-up prior to performing eccentric exercise, delayed-onset muscle soreness (DOMS) is mitigated and strength loss recovers faster. These benefits were observed primarily in nonresistance-trained individuals. The aim of this study was to determine if WBV could mitigate soreness and expedite strength recovery for resistance-trained individuals when used as a warm-up prior to eccentric exercise. Thirty resistance-trained males completed 300 maximal eccentric contractions of the quadriceps after warming up with (WBV) or without (CON) WBV. Both CON and WBV experienced significant isometric (27.8% and 30.5%, respectively) and …


Movement Competency's Relationship To Health Related Quality Of Life In Older Adults, Shaun M. Fulton Mar 2016

Movement Competency's Relationship To Health Related Quality Of Life In Older Adults, Shaun M. Fulton

Theses and Dissertations

The purpose of this study was to investigate the relationship between movement competency and health related quality of life (HRQOL) in adults aged 55 to 75 years. Seventy-eight, male (40) and female (38), subjects completed the study. Their mean (SD) age, height, and mass were 64.9 (5.8) years and 63.6 (4.9) years, 1.8 (.08) m and 1.7 (.07) m, 82.6 (11.8) kg and 70.3 (17.9) kg, for male and female, respectively. Subjects completed several tests in 3 categories: movement competency (Functional Movement ScreenTM [FMS] [all 7 tests], sitting-rising test [SRT]); physical activity level (Physical Activity Scale for the Elderly …


The Effect Of Aerobic Exercise Versus Inactivity On Nitric Oxide Concentration And Synthesis In An Elderly Population, Samantha Burton Dec 2015

The Effect Of Aerobic Exercise Versus Inactivity On Nitric Oxide Concentration And Synthesis In An Elderly Population, Samantha Burton

Theses and Dissertations

CONTEXT: Nitric Oxide (NO) is an endothelial-derived vasoactive molecule that causes an increase in blood flow and oxygen delivery to tissue. A reduction in NO bioavailability has been found to occur in adults over the age of 60 and can be reversed pharmacologically by improving NO synthase (NOS) activity. Reversing these age-related changes with alternative interventions, such as aerobic exercise, has shown some promising results. OBJECTIVE: To quantify blood NO-bioavailability (as measured by blood nitrite levels) in a population of aerobically trained elderly men and compare these data to a group of age-matched, inactive individuals. In addition, we measured the …


The Effect Of Foot Strengthening Exercise On Dynamic Function Of The Medial Longitudinal Arch In Runners: A Preliminary Report, Jarom Bridges Dec 2015

The Effect Of Foot Strengthening Exercise On Dynamic Function Of The Medial Longitudinal Arch In Runners: A Preliminary Report, Jarom Bridges

Theses and Dissertations

Therapeutic exercise has previously been shown to alter the static height of the medial longitudinal arch (MLA). It is still unknown, however, if these effects carry over into dynamic activities. PURPOSE: To determine if an 8-week foot strengthening exercise program increases static arch height and reduces vertical deformation of the MLA during mid-stance in running.METHODS: Thirty-four recreational runners (17 males, 17 females) have completed this ongoing study (age 24.06 ± 3.61 years, body mass 68.63 ± 12.95 kg, and height 173.34 ± 9.54 cm). To date, 22 subjects have been assigned to the control group (8 weeks of normal running) …


Blockade Of Tgf-Ss Signaling Through The Activin Type Iib Receptor With The Small Molecule, Sgi-1252, Jordan David Fuqua Dec 2015

Blockade Of Tgf-Ss Signaling Through The Activin Type Iib Receptor With The Small Molecule, Sgi-1252, Jordan David Fuqua

Theses and Dissertations

Antagonism of the activin receptor signaling pathway represents a promising potential therapy for the muscular dystrophies and other muscle wasting disorders (i.e., cachexia or sarcopenia). Previous research has shown that antagonism of activin signaling promotes muscle growth, attenuates muscle wasting, and restores function in both wild type and diseased animals. Our laboratory has recently developed a novel small molecule (SGI-1252) that inhibits activin downstream (i.e., Smad2/3 phosphorylation) signaling. Purpose: In this study we determined how eight weeks of orally administered SGI-1252 affected TGF-ß signaling, whole body mass, individual limb muscle mass, and muscle fiber cross sectional area (CSA). Methods: Wild-type …


Strength Training And Body Composition In Middle-Age Women, Rachelle Burrup Nov 2015

Strength Training And Body Composition In Middle-Age Women, Rachelle Burrup

Theses and Dissertations

OBJECTIVE: The purpose of this study was to examine the relationship between strength training and body composition before and after controlling for several covariates. A cross-sectional study including 257 female subjects was conducted. METHODS: Subjects' level of involvement in strength training was determined via questionnaire. Body composition was assessed using dual energy X-ray absorptiometry (DXA). Diet was assessed using 7-d weighed food records. RESULTS: Strong linear relationships between subjects' level of involvement in strength training and body composition were identified. For each additional day of strength training reported per week, body fat was 1.32 percentage points lower (F = 14.8, …


Will Ultrasound Performed With The Rich-Mar Autosound™ Be As Effective At Increasing Tissue Temperature As Ultrasound Performed With A Traditional Machine?, Heather Diane Black Jun 2015

Will Ultrasound Performed With The Rich-Mar Autosound™ Be As Effective At Increasing Tissue Temperature As Ultrasound Performed With A Traditional Machine?, Heather Diane Black

Theses and Dissertations

STUDY DESIGN: Randomized crossover experiment. OBJECTIVE: To determine whether the Rich-Mar AutoSound™ would be as effective as traditional ultrasound at increasing the temperature of the triceps surae muscle during a 10-min, 1 MHz, 1.0 W/cm2 ultrasound treatment. BACKGROUND: The AutoSound™ is a hands-free ultrasound device that is strapped on the body and left for the duration of the ultrasound treatment. It requires no clinician during the actual ultrasound treatment, thus freeing the clinician to perform other tasks and reducing clinician error during treatments. METHODS: 16 healthy subjects (6 males, 10 females, age = 22 ± 1.6 yrs, height = 173.2 …


Lower Extremity Neuromechanics During A Forward-Side Jump Following Functional Fatigue In Patients With Ankle Instability, Hyun Kim Jun 2015

Lower Extremity Neuromechanics During A Forward-Side Jump Following Functional Fatigue In Patients With Ankle Instability, Hyun Kim

Theses and Dissertations

Ankle instability (AI) and fatigue impair neuromuscular control as well as dynamic joint stability of the lower extremity. No one has comprehensively examined the effects of AI and fatigue on neuromechanics of the lower extremity during a functional activity. Deficits associated with AI and fatigue could be additive in increasing the risk for injury in patients with AI. PURPOSE: To examine the interaction of AI and fatigue on lower extremity muscle activity, kinematic, and kinetic patterns during a forward-side jump. METHODS: 25 AI (23.3 ± 1.9 yrs, 176.5 ± 10.5 cm, 70.9 ± 11.4 kg), and 25 matched control subjects …


Ground Forces Impact On Release Of Rotational Shot Put Technique, Niklas B. Arrhenius Dec 2014

Ground Forces Impact On Release Of Rotational Shot Put Technique, Niklas B. Arrhenius

Theses and Dissertations

In the shot put throw, the primary power is generated in the form of ground reaction forces as a result of action of the lower extremities (Coh, Stuhec, & Supej, 2008). The purpose of this study was to determine how the ground reaction force and ground contact time during the delivery phase of rotational shot put relates to the predicted distance of the throw. This will allow us to determine the optimal approach of force application for maximum throwing distance (Linthorne, 2001). Eight male subjects were used in this study (age 23 ± 4 y; body mass 123 ± 14 …


Microvascular Function In Metabolically Healthy Groups Differing In Bmi And Waist Circumference, Nathan R. Earl Dec 2014

Microvascular Function In Metabolically Healthy Groups Differing In Bmi And Waist Circumference, Nathan R. Earl

Theses and Dissertations

BACKGROUND: Microvascular dysfunction (MD: impaired performance of blood flow, tissue perfusion, blood pressure, etc.) is one of the earliest stages in the progression of various chronic diseases. OBJECTIVE: The aim of this study was to determine if a difference in microvascular function existed between two metabolically healthy groups that differed in BMI and waist circumference. DESIGN: This study employed a causal comparative design, with two groups: I) normal weight (n =14, BMI 28 kg/m2). METHODS: Microvascular function was assessed by measuring skin blood flow (SkBF) using laser Doppler flowmetry during postocclusive reactive hyperemia (PORH). The area under the SkBF time …


A Randomized Controlled Trial To Study The Effects Of Breakfast On Energy Intake, Physical Activity, And Body Fat In Women, Gabrielle Marie Lecheminant Dec 2014

A Randomized Controlled Trial To Study The Effects Of Breakfast On Energy Intake, Physical Activity, And Body Fat In Women, Gabrielle Marie Lecheminant

Theses and Dissertations

PURPOSE: The purpose of this study was to determine the effects of eating breakfast on energy intake, physical activity, body weight, and body fat in women who were nonhabitual breakfast eaters over a one-month period. METHODS: We tested 49 premenopausal, nonhabitual breakfast-eating women to compare the effects of eating breakfast versus not eating breakfast. Each participant was randomized to one of two conditions: breakfast or no breakfast. Breakfast eaters were required to eat within an hour and a half of awakening and had to be finished eating their breakfast meal by 8:30 A.M. Non-breakfast eaters were defined as not consuming …


The Effects Of Worksite Health Promotion Programs On Employee Biometric Data, Jamie M. Pratt Dec 2014

The Effects Of Worksite Health Promotion Programs On Employee Biometric Data, Jamie M. Pratt

Theses and Dissertations

INTRODUCTION: Worksite health promotion programs (WHPP) promote maintenance and changes of health-related behaviors of employees. Some companies opt to contract with a third party provider to implement a WHPP. PURPOSE: This study evaluated the participation rates, availability and use of health coaching, and changes in biometric data over a 2-year time period of employees in 13 companies for whom the WHPP was implemented by Wellness Corporate Solutions (WCS). METHODS: We had 2 years of biometric, health risk appraisal (HRA), or health coaching data on 4,473 employees. The statistical analysis included biometric screening data (percent body fat, body mass index (BMI), …


Unilateral Traditional Weight Lifting Generates Greatest Acute Upper Body Power Output, Evan H. Nakachi Oct 2014

Unilateral Traditional Weight Lifting Generates Greatest Acute Upper Body Power Output, Evan H. Nakachi

Theses and Dissertations

Bilateral deficit (BLD) is a phenomenon where the force generated from simultaneous bilateral limb contractions is less than the sum force generated by separate right and left limb contractions. There have been many BLD studies, but the measures of force generation have predominantly been with isometric and isokinetic contractions. There are, however, no dynamic upper body isotonic unilateral weight lifting studies on acute power output. The purpose of this study was to determine acute power output between bilateral and unilateral weight lifting under the conditions of traditional and circuit weight lifting. Seventeen male BYU rugby players (age = 21.8 ± …


Downhill Treadmill Running Does Not Induce Muscle Damage In Fvb Mice, Brenda Benson Sep 2014

Downhill Treadmill Running Does Not Induce Muscle Damage In Fvb Mice, Brenda Benson

Theses and Dissertations

Downhill treadmill running is a commonly used method to cause exercise-induced muscle damage, especially in rodents. Previous studies have evaluated which muscles in rats are more prone to damage. However research using downhill run mice (DHR) has shown some inconsistencies in which muscle is best analyzed for damage. Purpose: The purpose of this study was to quantify the damage in various muscles in a mouse after a single bout of DHR. Methods: Male FVB mice (5 months) were injected with Evans Blue dye (EBD) and then either used as control (CON) or run downhill (-16°) at 20 meters per minute …


Neural Reactivity To Visual Food Stimuli In The Morning And Evening: An Fmri Study In Women, Travis Daniel Masterson Aug 2014

Neural Reactivity To Visual Food Stimuli In The Morning And Evening: An Fmri Study In Women, Travis Daniel Masterson

Theses and Dissertations

Background: Visual food stimuli have been shown to influence desire to eat and may influence overall energy intake. The purpose of this study was to determine the influence, if any, that time of day has on the neural response to visual food stimuli, as measured by functional magnetic resonance imaging (fMRI). Methods: Using a crossover design, 15 healthy women were scanned using fMRI while presented with low- and high-energy pictures of food, once in the morning (6:30–8:30 am) and once in the evening (5:00–7:00 pm). Diets were identical on both days of the fMRI scans and were verified using weighed …


The Effect Of Chronic Mild To Moderate Neck Pain On Neck Function As Measured By Joint Reposition Error And Tactile Acuity Of The Cervical Dermatomes, Kelly Martell Cheever Jun 2014

The Effect Of Chronic Mild To Moderate Neck Pain On Neck Function As Measured By Joint Reposition Error And Tactile Acuity Of The Cervical Dermatomes, Kelly Martell Cheever

Theses and Dissertations

The purpose of this study was to observe the joint reposition error and tactile acuity of patients with chronic mild to moderate neck pain and compare those values to healthy controls to further investigate the effect of neck pain on neck function and the need for sensorimotor training in patients with chronic neck pain. In spite of some inconsistencies in the literature and methodology, both the two-point discrimination test and the joint reposition error test can give clinicians valuable, inexpensive and quick objective data that can be used in the diagnostic portion of an examination as well as in designing …


Validity Of Posturescreen Mobile® In The Measurement Of Standing Posture, Breanna Cristine Berry Hopkins Jun 2014

Validity Of Posturescreen Mobile® In The Measurement Of Standing Posture, Breanna Cristine Berry Hopkins

Theses and Dissertations

Background: PostureScreen Mobile® is an app created to quickly screen posture using front and side-view photographs. There is currently a lack of evidence that establishes PostureScreen Mobile® (PSM) as a valid measure of posture. Therefore, the purpose of this preliminary study was to document the validity and reliability of PostureScreen Mobile® in assessing static standing posture. Methods: This study was an experimental trial in which the posture of 50 male participants was assessed a total of six times using two different methods: PostureScreen Mobile® and Vicon 3D motion analysis system (VIC). Postural deviations, as measured during six trials of PSM …


The Acute Effects Of Patterned Electrical Neuromuscular Stimulation On Quadriceps Torque Production And Motor Unit Recruitment, John A. Derington Jun 2014

The Acute Effects Of Patterned Electrical Neuromuscular Stimulation On Quadriceps Torque Production And Motor Unit Recruitment, John A. Derington

Theses and Dissertations

Electric muscle stimulation (EMS) has been widely used in the rehabilitation of musculoskeletal injuries. Patterned electrical neuromuscular stimulation (PENS), a specific form of EMS, has been developed to better educate muscles to contract properly. The physiological efficacy of PENS has not been quantifiably identified. OBJECTIVES: The aim of this study is to determine the acute effect of one PENS training session (3 sets of 10 1-sec repetitions) on maximal isometric knee extensor (MVIC) torque production and surface EMG (sEMG) in healthy nonathlete college students. DESIGN: A randomized repeated-measures design was used in this study. METHODS: Twenty-two male college students participated …


The Effect Of Egoscue Corrective Exercises On Chronic Knee And Hip Pain, Zachary Vehrs Jun 2014

The Effect Of Egoscue Corrective Exercises On Chronic Knee And Hip Pain, Zachary Vehrs

Theses and Dissertations

INTRODUCTION: While strengthening and aerobic exercise have been shown to decrease chronic knee and hip pain, little is known about the effectiveness of Egoscue corrective exercises, which are intended to reduce musculoskeletal pain by bringing the body into postural alignment. PURPOSE: An experimental study to determine the acute effect following one treatment and the short-term effect after a 2 week program of Egoscue corrective exercises on knee pain, hip pain, and whole-body postural alignment. METHODS: Forty participants with chronic knee and/or hip pain (defined as pain on most days of the week for at least the previous 12 weeks) were …


Effects Of Tens On Voluntary Quadriceps Activation And Vertical Ground Reaction Force During Walking In Subjects With Experimental Knee Pain, Seong Jun Son May 2014

Effects Of Tens On Voluntary Quadriceps Activation And Vertical Ground Reaction Force During Walking In Subjects With Experimental Knee Pain, Seong Jun Son

Theses and Dissertations

Context: Knee pain is a common symptom in knee pathology and is associated with alterations in quadriceps activation and movement patterns. Reducing pain through intervention may help reestablish neuromuscular function. The independent effects of knee pain are difficult to examine and unclear. Objective: To investigate the effects of transcutaneous electrical nerve stimulation (TENS) on quadriceps activation and vertical ground reaction force (VGRF) during walking. Design: Crossover. Setting: Laboratory. Subjects: 15 in the TENS group (10M and 5F, 23.5 ± 2.8 yrs, 70.5 ± 12.5 kg, 178.1 ± 7.4 cm), and 15 in the sham group (10M and 5F, 22.5 ± …


The Influence Of Ambulation Speed And Corresponding Mechanical Variables On Articular Cartilage Metabolism, W. Matt Denning Apr 2014

The Influence Of Ambulation Speed And Corresponding Mechanical Variables On Articular Cartilage Metabolism, W. Matt Denning

Theses and Dissertations

During ambulation, lower-extremity joint angles and net moments influence knee joint load. It is unclear which mechanical variables most strongly correlate with acute articular cartilage (AC) catabolism in response to ambulation. Purpose: To determine which mechanical variables are most strongly correlated to acute AC catabolism, and to test the acute effect of ambulation speed on AC catabolism, while controlling for load frequency. Methods: 18 able-bodied subjects (9 male, 9 female; age = 23 ± 2 y; mass = 68.3 ± 9.6 kg; height = 1.70 ± 0.08 m) completed three separate ambulation sessions: slow (preferred walking speed), medium (+50% of …


The Acute Effects Of Whole-Body Corrective Exercise On Postural Alignment, Nicole Renee Rencher Mar 2014

The Acute Effects Of Whole-Body Corrective Exercise On Postural Alignment, Nicole Renee Rencher

Theses and Dissertations

This study examined the acute effects of whole-body corrective exercise on postural alignment in a sample of 50 male participants (18-30 y) displaying asymmetrical postural deviations. All participants were randomly assigned to either a non-exercise control (n = 25) or corrective exercise treatment (n = 25) group. A three-dimensional motion analysis Vicon system was employed to quantify standing postural alignment at the beginning and end of a 6 d study. Postural misalignments were determined in degrees of symmetry (tilt) and rotation using horizontal and vertical virtual plumb lines for the following locations: hip (ASIS), leg (greater trochanter), shoulder (acromion process), …


Achilles Tendon Changes In Downhill, Level And Uphill Running, Katy Andrews Neves Mar 2014

Achilles Tendon Changes In Downhill, Level And Uphill Running, Katy Andrews Neves

Theses and Dissertations

In this study, we examined how hill running affects the Achilles tendon, which is a common location for injuries in runners. Twenty females ran for 10 min on three randomly selected grades (-6%, 0%, +6%). Achilles tendon (AT) cross-sectional area (CSA) was imaged using Doppler ultrasound and peak vertical forces were analyzed using high-speed (240 Hz) videography. A metabolic cart and gas analyzer ensured a similar metabolic cost across grades. Data were analyzed using a forward selection regression. Results showed a decrease in AT CSA from pre-run to post-run (p = .0001). Peak vertical forces were different across grades (p …


The Effect Of Interval Training On Resting Blood Pressure, Camilla May Nielson Mar 2014

The Effect Of Interval Training On Resting Blood Pressure, Camilla May Nielson

Theses and Dissertations

Purpose: An experimental study to examine the effects of CardioWaves interval training (IT) and continuous training (CT) on resting blood pressure, resting heart rate, and mind-body wellness. Methods: Fifty-two normotensive (blood pressure <120/80 mmHg), pre-hypertensive (120-139/80-89 mmHg), and hypertensive (>140/90 mmHg) participants were randomly assigned and equally divided between the IT and CT groups. Both groups participated in the assigned exercise protocol thirty minutes per day, four days per week for eight weeks. Resting blood pressure, resting heart rate, and mind-body wellness were measured pre- and post-intervention. Results: A total of 47 participants (15 females and 32 males) were included in the analysis. The IT group had …


The Acute Effects Of Whole-Body Vibration Training On Passive And Dynamic Flexibility In Gymnasts, Caisa Nicole Brooks Dec 2013

The Acute Effects Of Whole-Body Vibration Training On Passive And Dynamic Flexibility In Gymnasts, Caisa Nicole Brooks

Theses and Dissertations

Gymnasts must attain extreme ranges of flexibility to execute performance requirements, thus effective stretching proves vital to advancement in the sport. This study examined the acute effects of whole-body vibration (WBV) on passive and dynamic flexibility in young, female gymnasts. Participants (n = 27, Junior Olympic levels 5-10) served as their own control. Measurements of passive and dynamic flexibility were obtained using the TOPS forward split testing method to examine passive flexibility and dynamic flexibility was measured via split jumps that were analyzed with video and Dartfish software. According to randomized order, all participants completed a stretching protocol either with …


Pharmacokinetics Of Dexamethasone Delivered Via Iontophoresis, Justin Holbrook Rigby Dec 2013

Pharmacokinetics Of Dexamethasone Delivered Via Iontophoresis, Justin Holbrook Rigby

Theses and Dissertations

Study Design: Controlled laboratory study. Objectives: To determine the time course of dexamethasone sodium phosphate (Dex-P) iontophoresis delivery to underlying tissues using microdialysis. Background: The efficacy of iontophoresis at delivering Dex-P through the skin is unknown in humans because of the lack of minimally invasive measurement techniques. Methods: Sixty-four healthy male participants (age = 24.4 ± 3.3 yrs, height = 71.8 ± 2.5 in, weight = 181.8 ± 26.1 lbs) were randomly assigned into one of six groups: 1) 1 mA current, 1 mm probes depth ; 2) 1 mA current, 4 mm probes depth; 3) 2 mA current, 1 …


Regulation Of The Myostatin Protein In Overload-Induced Hypertrophied Rat Skeletal Muscle, Paige Abriel Affleck Dec 2013

Regulation Of The Myostatin Protein In Overload-Induced Hypertrophied Rat Skeletal Muscle, Paige Abriel Affleck

Theses and Dissertations

Myostatin (GDF-8) is the chief chalone in skeletal muscle and negatively controls adult skeletal muscle growth. The role of myostatin during overload-induced hypertrophy of adult muscle is unclear. We tested the hypothesis that overloaded adult rodent skeletal muscle would result in reduced myostatin protein levels. Overload-induced hypertrophy was accomplished by unilateral tenotomy of the gastrocnemius tendon in male adult Sprague-Dawley rats followed by a two-week period of compensatory overload of the plantaris and soleus muscles. Western blot analysis was performed to evaluate changes in active, latent and precursor myostatin protein levels. Significant hypertrophy was noted in the plantaris (494 ± …