Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Biochemistry, Biophysics, and Structural Biology (3)
- Medicine and Health Sciences (3)
- Molecular Biology (3)
- Cell and Developmental Biology (2)
- Computational Biology (2)
-
- Amino Acids, Peptides, and Proteins (1)
- Anatomy (1)
- Animal Sciences (1)
- Bacteriology (1)
- Biochemistry (1)
- Bioinformatics (1)
- Biological Factors (1)
- Cancer Biology (1)
- Cells (1)
- Chemicals and Drugs (1)
- Developmental Biology (1)
- Diseases (1)
- Ecology and Evolutionary Biology (1)
- Genomics (1)
- Medical Immunology (1)
- Medical Microbiology (1)
- Medical Sciences (1)
- Microbiology (1)
- Nucleic Acids, Nucleotides, and Nucleosides (1)
- Ornithology (1)
- Other Ecology and Evolutionary Biology (1)
- Structural Biology (1)
- Institution
- Publication
- Publication Type
Articles 1 - 6 of 6
Full-Text Articles in Molecular Genetics
Dna Methylation By Restriction Modification Systems Affects The Global Transcriptome Profile In Borrelia Burgdorferi, Timothey Casselli, Yvonne Tourand, Adam Scheidegger, William K. Arnold, Anna Proulx, Brian Stevenson, Catherine A. Brissette
Dna Methylation By Restriction Modification Systems Affects The Global Transcriptome Profile In Borrelia Burgdorferi, Timothey Casselli, Yvonne Tourand, Adam Scheidegger, William K. Arnold, Anna Proulx, Brian Stevenson, Catherine A. Brissette
Microbiology, Immunology, and Molecular Genetics Faculty Publications
Prokaryote restriction modification (RM) systems serve to protect bacteria from potentially detrimental foreign DNA. Recent evidence suggests that DNA methylation by the methyltransferase (MTase) components of RM systems can also have effects on transcriptome profiles. The type strain of the causative agent of Lyme disease, Borrelia burgdorferi B31, possesses two RM systems with N6-methyladenosine (m6A) MTase activity, which are encoded by the bbe02 gene located on linear plasmid lp25 and bbq67 on lp56. The specific recognition and/or methylation sequences had not been identified for either of these B. burgdorferi MTases, and it was not previously known whether these RM …
Characterizing Epigenetic Regulation In The Developing Chicken Retina, Bejan Abbas Rasoul
Characterizing Epigenetic Regulation In The Developing Chicken Retina, Bejan Abbas Rasoul
Masters Theses, 2010-2019
The retina, the sensory neuronal tissue within the eye, is composed of three layers of neuronal cells connected by two synaptic layers lining the inside of the anterior portion of the eye. Multipotent retinal precursor cells are genetically homogeneous and differentiate into mature retinal neurons due to differential gene expression. Differences in gene expression have been correlated with epigenetic modifications such as DNA methylation. DNA methylation of upstream regulatory elements is associated with transcriptional silencing of gene expression. Years of research in retinal development has identified the numerous genes expressed during the main steps of retinal development, however, it is …
The Regulation Of Dna Methylation In Mammalian Development And Cancer, Nicolas Veland
The Regulation Of Dna Methylation In Mammalian Development And Cancer, Nicolas Veland
Dissertations & Theses (Open Access)
DNA methylation is an essential epigenetic modification in mammals, as it plays important regulatory roles in multiple biological processes, such as gene transcription, maintenance of chromosomal structure and genomic stability, genomic imprinting, retrotransposon silencing, and X-chromosome inactivation. Dysregulation of DNA methylation is associated with various human diseases. For example, cancer cells usually show global hypomethylation and regional hypermenthylation, which have been implicated in genomic instability and tumor suppressor silencing, respectively. Although great progress has been made in elucidating the biological functions of DNA methylation over the last several decades, how DNA methylation patterns and levels are regulated and dysregulated is …
Investigating The Impact Of Intragenic Dna Methylation On Gene Expression, And The Clinical Implications On Tumor Cells And Associated Stroma, Michael Mcguire
Investigating The Impact Of Intragenic Dna Methylation On Gene Expression, And The Clinical Implications On Tumor Cells And Associated Stroma, Michael Mcguire
Dissertations & Theses (Open Access)
Investigations into the function of non-promoter DNA methylation have yielded new insights into epigenetic regulation of gene expression. Previous studies have highlighted the importance of distinguishing between DNA methylation in discrete functional regions; however, integrated non-promoter DNA methylation and gene expression analyses across a wide number of tumor types and corresponding normal tissues have not been performed. Through integrated analysis of gene expression and DNA methylation profiles, we uncovered an enrichment of DNA methylation sites within the gene body and 3’UTR in which DNA methylation is strongly positively correlated with gene expression. We examined 32 tumor types and identified 57 …
The Effects Of Forest Degradation On Dna Methylation In Central African Songbirds, Andrew K. Wiegardt
The Effects Of Forest Degradation On Dna Methylation In Central African Songbirds, Andrew K. Wiegardt
Cal Poly Humboldt theses and projects
Environmentally-induced stress can initiate a molecular response through DNA methylation, which can alter gene expression, thereby serving as a mechanism allowing individuals to acclimate to a changing environment within their lifetime. In addition to DNA methylation, the production and release of corticosterone is a physiological mechanism by which birds can cope with acute environmental stressors. To assess how environmental stress impacted DNA methylation and corticosterone, I collected blood and feather samples from three understory avian species (Alethe castanea, Bleda notatus and Pseudalethe poliocephala), along a disturbance gradient in the lowland Guinean rainforest adjacent to the village of …
In Silico Modeling Of Epigenetic-Induced Changes In Photoreceptor Cis-Regulatory Elements, Reafa A. Hossain, Nicholas R. Dunham, Raymond A. Enke, Christopher E. Berndsen
In Silico Modeling Of Epigenetic-Induced Changes In Photoreceptor Cis-Regulatory Elements, Reafa A. Hossain, Nicholas R. Dunham, Raymond A. Enke, Christopher E. Berndsen
Ray Enke Ph.D.
No abstract provided.