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Full-Text Articles in Molecular Genetics
Snd1-Targeted Gene Therapy For Hepatocellular Carcinoma, Bryan D. Mckiver
Snd1-Targeted Gene Therapy For Hepatocellular Carcinoma, Bryan D. Mckiver
Theses and Dissertations
Staphylococcal nuclease and tudor-domain containing 1 (SND1) is an oncogene for a wide variety of cancers, including hepatocellular carcinoma (HCC). SND1 is a multifunctional protein regulating gene expression of proto-oncogenes and tumor suppressor genes, making SND1 a prime target for developing cancer therapeutics. This notion is especially attributed to HCC as most patients are diagnosed in advanced stages and the therapeutic options available for these patients are severely limited. In this study, we evaluated the therapeutic potential of a replication-defective adenovirus vector delivering SND1 shRNA (Ad.SND1sh) to human HCC cell lines, HepG3, HuH-7, and Hep3B. Adenovirus infection in HCC cells …
Snd1 Mediated Downregulation Of Ptpn23 In Hcc, Nidhi Jariwala
Snd1 Mediated Downregulation Of Ptpn23 In Hcc, Nidhi Jariwala
Theses and Dissertations
SND1 MEDIATED DOWNREGULATION OF PTPN23 IN HEPATOCELLULAR CARCINOMA
By Nidhi Jariwala, MS
A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University, 2014.
ADVISOR: Dr. Devanand Sarkar
Associate Professor, Department of Human and Molecular Genetics Blick Scholar Associate Scientific Director, Cancer Therapeutics VCU Institute of Molecular Medicine Massey Cancer Center
ABSTRACT
Staphyloccocal nuclease domain containing protein 1 (SND1) is identified as an oncogene in multiple cancers, including hepatocellular carcinoma (HCC). SND1 regulates gene expression at transcriptional as well as post-transcriptional level and mediates molecular pathways that culminate into carcinogenesis. SND1 …