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Full-Text Articles in Genomics
Global Analysis Of Drosophila Cys2-His2 Zinc Finger Proteins Reveals A Multitude Of Novel Recognition Motifs And Binding Determinants, Metewo Selase Enuameh, Yuna Asriyan, Adam Richards, Ryan G. Christensen, Victoria L. Hall, Majid Kazemian, Cong Zhu, Hannah Pham, Qiong Cheng, Charles Blatti, Jessie A. Brasefield, Matthew D. Basciotta, Jianhong Ou, Joseph C. Mcnulty, Lihua Julie Zhu, Susan E. Celniker, Saurabh Sinha, Gary D. Stormo, Michael H. Brodsky, Scot A. Wolfe
Global Analysis Of Drosophila Cys2-His2 Zinc Finger Proteins Reveals A Multitude Of Novel Recognition Motifs And Binding Determinants, Metewo Selase Enuameh, Yuna Asriyan, Adam Richards, Ryan G. Christensen, Victoria L. Hall, Majid Kazemian, Cong Zhu, Hannah Pham, Qiong Cheng, Charles Blatti, Jessie A. Brasefield, Matthew D. Basciotta, Jianhong Ou, Joseph C. Mcnulty, Lihua Julie Zhu, Susan E. Celniker, Saurabh Sinha, Gary D. Stormo, Michael H. Brodsky, Scot A. Wolfe
Michael Brodsky
Cys2-His2 zinc finger proteins (ZFPs) are the largest group of transcription factors in higher metazoans. A complete characterization of these ZFPs and their associated target sequences is pivotal to fully annotate transcriptional regulatory networks in metazoan genomes. As a first step in this process, we have characterized the DNA-binding specificities of 129 zinc finger sets from Drosophila using a bacterial one-hybrid system. This data set contains the DNA-binding specificities for at least one encoded ZFP from 70 unique genes and 23 alternate splice isoforms representing the largest set of characterized ZFPs from any organism described to date. These recognition motifs …