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Full-Text Articles in Genomics
Contributions Of Gene Copy Number Variation To Genome Evolution And Local Adaptation Of The Cyanobacterium Acaryochloris, Amy L. Gallagher
Contributions Of Gene Copy Number Variation To Genome Evolution And Local Adaptation Of The Cyanobacterium Acaryochloris, Amy L. Gallagher
Graduate Student Theses, Dissertations, & Professional Papers
Acaryochloris is a recently discovered genus of cyanobacteria, unique in its use of an uncommon chlorophyll as its major photosynthetic pigment, and in its peculiar genome dynamics. Members of this genus exhibit increased genic copy number variation (CNV), which is thought to be primarily derived from gene duplications and horizontal gene transfer (HGT). Acaryochloris provides an ideal system to explore mechanisms behind maintenance of gene duplicates and the influence of CNV in local adaptation. Here, I propose a mechanism for retention of gene duplicates of the bacterial recombinase, RecA, in Acaryochloris genomes and provide preliminary evidence that these paralogs are …
Somatic Copy Number Mosaicism Contributes To Genomic Diversity In Mus Musculus, Andrea E. Wishart
Somatic Copy Number Mosaicism Contributes To Genomic Diversity In Mus Musculus, Andrea E. Wishart
Electronic Thesis and Dissertation Repository
Copy number variants (CNVs) are a source of genomic variation associated with altered phenotypes. Somatic copy number mosaicism results when different populations of cells in an individual differ due to de novo copy number changes (CNCs). Tissue-specific patterns of CNCs resulting in mosaicism have yet to be characterized in the mouse, an organism frequently used to model human diseases. Here, DNA was sampled from spleen, liver, and cerebellum of eight highly related mice selected from a familial unit. CNVs and CNCs were detected using the Mouse Diversity Genotyping Array with three computational methods (ConsecN, Partek, and PennCNV). Tissue-specific patterns of …