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Full-Text Articles in Genomics
Building The Genomic Base-Layer Of The Oral “Omic” World, The Forsyth Metagenomic Support Consortium, Jacques Izard
Building The Genomic Base-Layer Of The Oral “Omic” World, The Forsyth Metagenomic Support Consortium, Jacques Izard
Department of Food Science and Technology: Faculty Publications
With the shift of molecular technologies directed toward the understanding of greater biological complexity of the oral cavity, a knowledge gap was created by the lack of genomic data from the diverse oral microorganisms. To facilitate and enable the interpretation of metagenomic, transcriptomic, and proteomic data generated or soon to be generated from oral biofilms, we are providing reference genomic information from phylogenetically diverse oral bacterial isolates. This work, initiated by the National Institute of Dental and Craniofacial Research as an isolated effort, is now part of the Human Microbiome Project. The goal of this effort is the public release …
Tannerella Forsythia, A Periodontal Pathogen Entering The Genomic Era, Anne C.R. Tanner, Jacques Izard
Tannerella Forsythia, A Periodontal Pathogen Entering The Genomic Era, Anne C.R. Tanner, Jacques Izard
Department of Food Science and Technology: Faculty Publications
Several questions need to be addressed to evaluate whether Tannerella forsythia is to be considered a periodontal pathogen. T. forsythia has been detected in periodontal health and disease, so could it be a pathogen? The species was not detected in many studies despite finding other putative pathogens, so could it be important in pathogenicity? The challenges of working with T. forsythia include its fastidious and anaerobic growth requirements for cultural detection. Thus, studies associating T. forsythia with periodontal and other oral infections have used noncultural approaches (immunoassays and DNA-based assays) in addition to cultural approaches. We feel the timing of …