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Articles 1 - 6 of 6
Full-Text Articles in Genetics and Genomics
Epigenetics In Forensic Science, Reagan Faunce
Epigenetics In Forensic Science, Reagan Faunce
Honors Projects
DNA methylation can be useful for forensic scientists because it can be used to differentiate between the DNA of identical twins, determine the age of a contributor of a DNA sample, and help us understand the actions and tendencies of violent criminals. Research shows that DNA methylation changes over time and can be caused by traumatic events, suggesting that methylation increases with age. Prior studies of DNA methylation at the promoters of the EDARADD, TOM1L1, and NPTX2 genes have been able to predict age within 5.2 years and a study of the ASPA, EDARADD, PDE4C, and ELOVL2 genes predicted age …
The Synthesis And Purification Methodology Of An Intermolecular Pyrophosphate Sensor: Applications For The Quantitative Polymerase Chain Reaction, Ethan Gevedon
Honors Projects
The optimized synthesis and purification methodology for an intermolecular pyrophosphate sensor scaffold molecule was performed: high performance liquid chromatography afforded the scaffold in excellent purity and yield. The applications of the sensor assembly in the quantitative polymerase chain reaction were discussed, and preliminary results show that
Genetics With Nettie And Friends: An Exploration Of Genetics In Children's Literature, Erin Soule, Madeleine Gray Burland
Genetics With Nettie And Friends: An Exploration Of Genetics In Children's Literature, Erin Soule, Madeleine Gray Burland
Honors Projects
Genetics with Nettie and Friends is an exploration of chromosomal disorders and its place within children's literature. The book provides a comprehensive examination the genetic composition of Downs syndrome, Williams Syndrome, and Duchenne muscular dystrophy at a level to increase understanding in children. This paper provides an insight to the development and construction of the children's book that is available for purchase on Barnes and Noble as well as why representation of genetic disorders in children's literature is needed.
Effect Of Maternal Age On Recombination Rate In Drosophila Melanogaster, Christopher Schimmoeller
Effect Of Maternal Age On Recombination Rate In Drosophila Melanogaster, Christopher Schimmoeller
Honors Projects
Recombination is vital because it adds genetic diversity to a species and has the potential to influence fitness, the relative reproductive success of an organism in passing genes to the next generation (Roeder, 1997). Multiple aspects of recombination have been studied, including its mechanisms of production and the role of recombination events in evolution (Hudson & Kaplan, 1985). In this study we examined how maternal age affects the rate of recombination. Our hypothesis states that recombination rate is positively correlated with maternal age. If this is true we would expect to see recombination rate, in progeny, increase as the parental …
Bacteriophage Ems9: Preliminary Genomic Description, Hallie Rae Zimmer
Bacteriophage Ems9: Preliminary Genomic Description, Hallie Rae Zimmer
Honors Projects
EMS9 is a bacteriophage that was recently isolated from an Escherichia coli strain present in horse feces. Bacteriophage EMS9 consists of 98,771 base pairs that are organized into 139 predicted open reading frames (ORFs). These predicted genes potentially encode specific bacteriophage proteins. The genomic sequence of bacteriophage EMS9 is arranged intro three groups: early, middle, and late genes. Considerable homology between the ORFs of bacteriophage EMS9 and bacteriophages T5 and H8 exists. All of these bacteriophages are believed to use a rare two-step transfer mechanism to invade host cells. This annotation of the genomic sequence of EMS9 will provide a …
Characterization Of A Novel Clade Of Transporters In Phytophthora, Stephanie Padula, Paul F. Morris Dr, Howard Casey Cromwell Dr., Menaka Ariyaratne, Andrew Wagner
Characterization Of A Novel Clade Of Transporters In Phytophthora, Stephanie Padula, Paul F. Morris Dr, Howard Casey Cromwell Dr., Menaka Ariyaratne, Andrew Wagner
Honors Projects
The oomycete Phytophthora parasitica has a worldwide distribution and is an economically important pathogen of more than 100 species4. RNA-seq analysis showed that one gene, PPTG_16698 has the 5th highest level of expression of all transport proteins in the zoospore stage, and is highly conserved throughout Phytophthora species. This project attempts to characterize the important biological role that PPTG_16698 plays in P. parasitica and other oomycetes. Three strategies have been implemented to accomplish this goal: growth analysis by heterologous expression in yeast, metabolite analysis in yeast, and construction of a GFP fusion protein to enable localization of …