Open Access. Powered by Scholars. Published by Universities.®
Other Ecology and Evolutionary Biology Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Other Ecology and Evolutionary Biology
Mechanisms Of Carnitine-Mediated Modulation Of Aflatoxin B1-Dna Adduct Formation, Ayub Mohd Yatim
Mechanisms Of Carnitine-Mediated Modulation Of Aflatoxin B1-Dna Adduct Formation, Ayub Mohd Yatim
Doctoral Dissertations
The main purpose of this study was to investigate the possible mechanism(s) of L-carnitine-mediated modulation of AFB1-DNA adducts formation. The first part of the study investigated the effect of increased doses of carnitine on AFB1 binding to macromolecules, AFB1 uptake, activity of glutathione S-transferase (GST), and total glutathione concentrations in freshly isolated hepatocytes. Carnitine dose was significantly correlated with the formation of AFB1-DNA adduct ( r = -0.68;p = 0.0002 ), AFB1-protein adduct (r = 0.58;p = 0.017), but not AFB1-RNA adduct (r = 0.14;p = 0.604). …