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Full-Text Articles in Cell Biology
Hexabromocyclododecane Decreases Tumor-Cell-Binding Capacity And Cell-Surface Protein Expression Of Human Natural Killer Cells, Natasha C. Hinkson, Margaret M. Whalen
Hexabromocyclododecane Decreases Tumor-Cell-Binding Capacity And Cell-Surface Protein Expression Of Human Natural Killer Cells, Natasha C. Hinkson, Margaret M. Whalen
Chemistry Faculty Research
Hexabromocyclododecane (HBCD) is a flame retardant that decreases the lytic function of human natural killer (NK) cells. NK cells defend against tumor cells and virally infected cells. Thus, HBCD has the potential to increase cancer incidence and viral infections. NK cells must bind to their targets for lysis to occur. Thus, concentrations of HBCD that decrease lytic function were examined for their ability to alter NK binding to tumor targets. Levels of HBCD that caused a loss of binding function were examined for effects on expression of cell surface proteins needed for binding. NK cells exposed to HBCD for 24 …
Hexabromocyclododecane Decreases The Lytic Function And Atp Levels Of Human Natural Killer Cells, Natasha C. Hinkson, Margaret M. Whalen
Hexabromocyclododecane Decreases The Lytic Function And Atp Levels Of Human Natural Killer Cells, Natasha C. Hinkson, Margaret M. Whalen
Chemistry Faculty Research
This study investigates the effect of hexabromocyclododecane (HBCD) on the lytic function of human natural killer (NK) cells and on ATP levels in NK cells. NK cells are capable of lysing tumor cells, virally infected cells, and antibody-coated cells. HBCD is a brominated cyclic alkane used primarily as an additive flame retardant. If HBCD interferes with NK cell function, this could increase risk of tumor development and/or viral infection. NK cells were exposed to various concentrations of HBCD for 24 and 48 h and 6 days before determining lytic function and ATP levels. ATP levels and lytic function were also …