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Full-Text Articles in Cell Biology
Preparation, Separation, Purification, Characterization And Human Cell Line Anti-Cancer Evaluation Of Rice Bran Peptides, Arvind Kannan
Preparation, Separation, Purification, Characterization And Human Cell Line Anti-Cancer Evaluation Of Rice Bran Peptides, Arvind Kannan
Graduate Theses and Dissertations
Bioactive compounds are revolutionizing the nutritional and medicinal world with their inherent disease-fighting properties. A wide range of functional groups fall under the category of imparting health benefits. Compounds from both animal and plant origins have been generated as bioactive agents that have opened up new vistas for alternative medicine and natural healing. For example, in a debilitating disease like cancer, these compounds can act to suppress or delay the underlying pathology over and above the conventional treatment strategies involving drugs or chemotherapy. In other words conventional and invasive therapy, although still considered appropriate at certain stages of cancer, their …
Live-Cell Studies On Mitotic Slippage In Humans, Daniela A. Brito
Live-Cell Studies On Mitotic Slippage In Humans, Daniela A. Brito
Legacy Theses & Dissertations (2009 - 2024)
Checkpoints are regulatory pathways that control the order and timing of specific cell-cycle events. In the presence of unattached/weakly-attached kinetochores, the mitotic checkpoint (MC) arrests cells in mitosis by inhibiting the degradation of cyclin B, the regulatory subunit of Cdk1 (cyclin dependent kinase 1). Checkpoints do not arrest cells permanently, and escaping mitosis with an unsatisfied MC requires cyclin B/Cdk1 inactivation. In yeast, this occurs through an “adaptation” mechanism involving inhibitory phosphorylations and/or Cdk1-inhibitors. To determine how vertebrate cells escape mitosis when the MC cannot be satisfied I conducted live-cell imaging and immunofluorescence studies on nocodazole-treated rat kangaroo (PtK) and …