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Construction And Characterization Of A Novel Fusion Protein From The Extracellular Domain Of Mult1 And Transmembrane And Intracellular Domains Of Fas And Its Therapeutic Evaluation For Cancer Treatment Using An Adenoviral Delivery System, Hari Shankar Kotturi Rajeshwar

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One of the strategies that tumor cells adopt to evade immunosurveillance mounted by elements of the innate immune system, such as NK cells, is to down-regulate certain cell surface molecules through a process also called shedding. Mouse UL16-binding protein-like transcript 1 (MULT1), which can activate NK cells through NK cell receptor NKG2D, is one of such molecules. Tumor cells can also avoid Fas mediated apoptosis by down-regulating its expression, secreting antagonistic `decoy' receptors, or expressing anti-apoptotic molecules. In this study, we report the design and evaluation of the antitumor activity of a novel fusion protein MULT1E/FasTI, consisting of the extracellular …