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Full-Text Articles in Cell Biology
Tetrabromobisphenol A Has Immunosuppressive Effects On Human Natural Killer Cells, Esther Caroline Kibakaya, Krishna Stephen, Margaret M. Whalen
Tetrabromobisphenol A Has Immunosuppressive Effects On Human Natural Killer Cells, Esther Caroline Kibakaya, Krishna Stephen, Margaret M. Whalen
Chemistry Faculty Research
Human natural killer (NK) cells are lymphocytes that destroy tumor cells, virally-infected cells, and antibody-coated cells. Tetrabromobisphenol A (TBBPA) is used both as a reactive and as an additive flame retardant in a variety of materials and appears to contaminate the environment. TBBPA has been found in human blood samples and if it interferes with NK cell function, this could increase the risk of tumor development and/or viral infection. The present study examines the effects of exposure to various concentrations of TBBPA for 24 hr, 48 hr, and 6 days on the lytic function, tumor-target-binding function, and ATP levels of …
Hexabromocyclododecane Decreases The Lytic Function And Atp Levels Of Human Natural Killer Cells, Natasha C. Hinkson, Margaret M. Whalen
Hexabromocyclododecane Decreases The Lytic Function And Atp Levels Of Human Natural Killer Cells, Natasha C. Hinkson, Margaret M. Whalen
Chemistry Faculty Research
This study investigates the effect of hexabromocyclododecane (HBCD) on the lytic function of human natural killer (NK) cells and on ATP levels in NK cells. NK cells are capable of lysing tumor cells, virally infected cells, and antibody-coated cells. HBCD is a brominated cyclic alkane used primarily as an additive flame retardant. If HBCD interferes with NK cell function, this could increase risk of tumor development and/or viral infection. NK cells were exposed to various concentrations of HBCD for 24 and 48 h and 6 days before determining lytic function and ATP levels. ATP levels and lytic function were also …