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Full-Text Articles in Cell Biology
The Role Of The Cell-Surface Protease Tmprss13 In Colorectal Cancer, Fausto Alexander Varela
The Role Of The Cell-Surface Protease Tmprss13 In Colorectal Cancer, Fausto Alexander Varela
Wayne State University Dissertations
Colorectal cancer (CRC) is one of the most common and deadly cancers in both men and women in the United States. Extracellular proteolysis is often dysregulated in cancer including (CRC), resulting in degradation of extracellular matrix, as well as cleavage, processing, or shedding of cell adhesion molecules, growth factors, and cytokines. Several members of the type II transmembrane serine protease (TTSP) family have been shown to play critical roles in cancer progression; however, many family members have not yet been characterized in malignancy. We identified TMPRSS13 transcript to be upregulated in CRC compared to normal colon. This increase was confirmed …
Identifying The Role Of The Type-Ii Transmembrane Serine Protease Tmprss13 In Breast Cancer, Andrew Stevan Murray
Identifying The Role Of The Type-Ii Transmembrane Serine Protease Tmprss13 In Breast Cancer, Andrew Stevan Murray
Wayne State University Dissertations
Breast cancer is the most frequently diagnosed cancer and the second leading cause of cancer death in women in the United States. Breast cancer progression is accompanied by increased expression of extracellular and cell surface proteases that are capable of degrading the extracellular matrix as well as cleaving and activating downstream targets. These proteolytic processes are critically involved in modifying the tissue microenvironment of the breast, which is necessary for cancer cell invasion and eventual dissemination of cancer cells to other organs. Therefore, identifying novel proteases that promote tumor progression is critical to create new approaches for developing improved breast …