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Full-Text Articles in Cell Biology
Delayed Anesthetic Preconditioning And Metallothioneins I+Ii: Novel Mediators Of Anesthetic-Induced Protection, Scott David Edmands
Delayed Anesthetic Preconditioning And Metallothioneins I+Ii: Novel Mediators Of Anesthetic-Induced Protection, Scott David Edmands
Open Access Dissertations
Ischemic injury is a common and debilitating outcome of natural illness and as a complication of commonly performed medical procedures. Whereas naturally occurring ischemic insults are often the result of unpredictable events, such as in the case of stroke or heart attack, the risk of operative and perioperative ischemia is somewhat better characterized in the clinical setting. Given the prevalence and severity of outcomes in ischemic injury, there is significant interest in developing better pharmacological and procedural approaches to improve patient outcomes. One approach that has shown significant promise in the laboratory setting, particularly in the context of planned medical …
Modulation Of Macrophage Responses To Borrelia Burgdorferi In Acute Murine Lyme Carditis, Chris Martin Olson
Modulation Of Macrophage Responses To Borrelia Burgdorferi In Acute Murine Lyme Carditis, Chris Martin Olson
Open Access Dissertations
The Lyme disease spirochete Borrelia burgdorferi is the only known human pathogen that directly activates invariant natural killer T (iNKT) cells. The number and activation kinetics of iNKT cells vary greatly among different strains of mice. Here, we report the role of the iNKT cell response in the pathogenesis of Lyme disease using C57BL/6 (B6) mice, a strain with optimal iNKT cell activation that is resistant to the development of spirochetal-induced inflammation. During experimental infection of B6 mice with B. burgdorferi , iNKT cells localize to the inflamed heart where they are activated by CD1d-expressing macrophages. Activation of iNKT cells …
The Conformational Gymnastics Of The Escherichia Coli Seca Molecular Machine And Its Interactions With Signal Sequences, Jenny Lynn Maki
The Conformational Gymnastics Of The Escherichia Coli Seca Molecular Machine And Its Interactions With Signal Sequences, Jenny Lynn Maki
Open Access Dissertations
Protein secretion is a selective and regulated process that is essential in all organisms. In bacteria the preprotein translocase SecA, either free in the cytosol or associated with the SecYEG translocon, recognizes and binds most post-translational secretory proteins containing an N-terminal signal sequence. In Gram-negative bacteria, the molecular chaperone SecB binds many of the preproteins to keep them in a translocation-competent state. Subsequently, SecB delivers the preproteins to the translocon-associated SecA, which binds the signal sequence and also interacts with mature regions of the preprotein. After the preprotein/SecA/SecYEG complex has formed, the energy derived from ATP hydrolysis by SecA coupled …