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Activation Of Nf-Κb Transcription Factor During In Vitro Differentiation Of Mouse Embryonic Stem Cells, Natalya A. Ortolano
Activation Of Nf-Κb Transcription Factor During In Vitro Differentiation Of Mouse Embryonic Stem Cells, Natalya A. Ortolano
Honors Theses
Embryonic stem cells (ESCs) are a promising cell source for regenerative medicine. However, recent studies indicated that ESCs and ESC-derived cells (ESC-DCs) lack functional innate immunity against various pathogens and inflammatory cytokines. This presents a barrier to clinical application, as ESC-DCs would be placed in a wound site and exposed to pathogens and inflammatory cytokines. Using mouse ESCs (mESCs) as a model, we recently demonstrated that they are deficient in expressing type I interferons (IFN) and inflammatory cytokines. To determine the molecular basis for this finding, this study examined the activation state of nuclear factor-κB (NF-κB), a transcription factor that …