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Articles 1 - 3 of 3
Full-Text Articles in Cell Biology
The Role Of Human Endogenous Retroviruses In Renal Cell Carcinoma, Michele D. Tisdale
The Role Of Human Endogenous Retroviruses In Renal Cell Carcinoma, Michele D. Tisdale
Biological Sciences Theses & Dissertations
Human endogenous retroviruses make up approximately 8-9% of the human genome. A number of expressed HERVs, those that are actively transcribing, have been associated with various cancers. Suppression mechanisms that control HERV expression often fail or become more permissive in tissues where expression should be restricted. Previous studies have identified HERV expression in breast cancer tissues, whereas normal tissue HERV expression remained suppressed. In addition, studies of DNA hypermethylation have correlated with the ability to contribute to cancer development. Hypermethylation of several tumor suppressor genes occurs frequently in cancers and alterations in promoter regions could contribute to the development of …
Study Of The Dna Damage Complexes Within The Htlv-1 Tax Oncoprotein Interactome, Sidi Mehdi Belgnaoui
Study Of The Dna Damage Complexes Within The Htlv-1 Tax Oncoprotein Interactome, Sidi Mehdi Belgnaoui
Theses and Dissertations in Biomedical Sciences
Human T-cell leukemia virus type 1 (HTLV-1) is a transforming retrovirus that can give rise to adult T-cell leukemia (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Tax is a virally encoded oncoprotein that is involved in HTLV-1 mediated cellular transformation. It has been hypothesized that Tax induces genomic instability via repression of the cellular DNA damage repair response. Our laboratory has previously shown that the interaction between Tax and various proteins involved in the DNA-damage response pathway impairs the ability of these proteins to mount an efficient repair response. As part of these observations, we proposed that Tax induces …
Peripheral Dendritic Cells Are Essential For Both The Innate And Adaptive Antiviral Immune Responses In The Central Nervous System, Christina D. Steel, Suzanna M. Hahto, Richard P. Ciavarra
Peripheral Dendritic Cells Are Essential For Both The Innate And Adaptive Antiviral Immune Responses In The Central Nervous System, Christina D. Steel, Suzanna M. Hahto, Richard P. Ciavarra
Biological Sciences Faculty Publications
Intranasal application of vesicular stomatitis virus (VSV) causes acute infection of the central nervous system (CNS). However, VSV encephalitis is not invariably fatal, suggesting that the CNS may contain a professional antigen-presenting cell (APC) capable of inducing or propagating a protective antiviral immune response. To examine this possibility, we first characterized the cellular elements that infiltrate the brain as well as the activation status of resident microglia in the brains of normal and transgenic mice acutely ablated of peripheral dendritic cells (DCs) in vivo. VSV encephalitis was characterized by a pronounced infiltrate of myeloid cells (CD45highCD11b+ …