Cell Biology Commons^™

Activation Of Protein Kinase C And Protein Kinase D In Human Natural Killer Cells: Effects Of Tributyltin, Dibutyltin, And Tetrabromobisphenol A, Krupa Rana, Margaret Whalen

Chemistry Faculty Research

Up to now, the ability of target cells to activate protein kinase C (PKC) and protein kinase D (PKD) (which is often a downstream target of PKC) has not been examined in natural killer (NK) lymphocytes. Here we examined whether exposure of human NK cells to lysis sensitive tumor cells activated PKC and PKD. The results of these studies show for the first time that activation of PKC and PKD occurs in response to target cell binding to NK cells. Exposure of NK cells to K562 tumor cells for 10 and 30 min increased phosphorylation/activation of both PKC and PKD …