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Full-Text Articles in Cell Biology
Jak3/Stat5 Signaling Cascade Represents A Therapeutic Target To Treat Select Hematologic Malignancies, Damaris Rosado
Jak3/Stat5 Signaling Cascade Represents A Therapeutic Target To Treat Select Hematologic Malignancies, Damaris Rosado
Open Access Theses & Dissertations
Tyrosine kinases are an essential component of cell signal transduction pathways, many of which promote cellular proliferation. However, when a tyrosine kinase is aberrantly activated or its negative regulation is lost, the result can be malignancy. In humans, 90 tyrosine kinases are present and of these, 51 have been linked to a malignancy through mutation or overexpression. Janus kinase 3 (JAK3) is one such kinase that upon hyperactivation, due to a somatic mutation, has been linked to cancer including its substrate, signal transducer and activator of transcription (STAT5). Few studies have investigated the role of JAK3/STAT5 pathways in hematopoietic cancers …
Microelement Localization In Leaves Of Populus Spp. And Tolerance Mechanisms To Boron-Salt Toxicity, Daniel Arriaga
Microelement Localization In Leaves Of Populus Spp. And Tolerance Mechanisms To Boron-Salt Toxicity, Daniel Arriaga
Open Access Theses & Dissertations
Phytoremediation has been proposed as a low-cost, environmentally friendly alternative to clean highly contaminated sites. Phytoremediation using trees offer the advantage of metal immobilization (phytostabilization), high hydraulic pumping pressures, produce large plant biomass, absorption of total dissolved salts within their tissue, long life spans, less frequent irrigation and, a massive root system that helps soil attachment. Hybrid poplar varieties are long-lived, perennial, fast growing, and produce a large amount of foliage to harvest. Boron is an essential micronutrient for plants. Certain locations, such as California and Turkey, have suffered from high boron efflux from irrigation waters. It has been identified …
Arachidonic Acid Signaling In Invasive And Non-Invasive Breast Cancer Cells, Debarshi Roy
Arachidonic Acid Signaling In Invasive And Non-Invasive Breast Cancer Cells, Debarshi Roy
Open Access Theses & Dissertations
Breast cancer is the second largest cause of cancer-related deaths in women all over the world. Epidemiological studies suggest that the consumption of high-fat diets can promote the incidence of breast cancers in both developed and developing countries. In particular, the lipid-rich diet contains arachidonic acid (AA, a C20:4 polyunsaturated fatty acid), which has been shown to be associated with tumor formation in breast tissues. Nevertheless, the actual mechanism by which AA induces the metastatic transformation and malignancy is not well understood. The goal of my dissertation, therefore, is to identify the molecules and unravel the pathways that participate in …