Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
- Publication
- Publication Type
Articles 1 - 3 of 3
Full-Text Articles in Cell Biology
Identification And Functional Characterization Of The Zebrafish Gene Quetschkommode (Que), Timo Friedrich
Identification And Functional Characterization Of The Zebrafish Gene Quetschkommode (Que), Timo Friedrich
Open Access Dissertations
Locomotion in vertebrates depends on proper formation and maintenance of neuronal networks in the hind-brain and spinal cord. Malformation or loss of factors required for proper maintenance of these networks can lead to severe neurodegenerative diseases limiting or preventing locomotion. A powerful tool to investigate the genetic and cellular requirements for development and/or maintenance of these networks is a collection of zebrafish mutants with defects in motility. The zebrafish mutant quetschkommode (que) harbors a previously unknown gene defect leading to abnormal locomotor behavior. Here I show that the que mutants display a seizure-like behavior starting around four days post fertilization …
Target Recognition And Competitive Synaptogenesis In The Drosophila Giant Fiber System, Jason Joseph Hill
Target Recognition And Competitive Synaptogenesis In The Drosophila Giant Fiber System, Jason Joseph Hill
Open Access Dissertations
The development of complex neural networks relies on a careful balance of environmental cues to guide and shape both ends of the eventual connection. However, the correct wiring of circuits whose components share molecular profiles depends on a more elaborate phenomenon, competition. Despite being highly studied, there is still a lack of understanding as to the mechanism that allows molecularly identical cells to form exclusive connections with their targets. To address this complex question, we turned to a simple circuit within the genetically tractable fly. Responsible for the escape reflex, the Giant Fiber System is comprised of bilaterally symmetrical axons …
Transient Pharmacologic Lowering Of Aβ Production Prior To Deposition Results In Sustained Reduction Of Amyloid Plaque Pathology, Pritam Das, Christophe Verbeeck, Lisa Minter, Paramita Chakrabarty, Kevin Felsenstein, Thomas Kukar, Ghulam Maharvi, Abdul Fauq, Barbara A. Osborne, Todd E. Golde
Transient Pharmacologic Lowering Of Aβ Production Prior To Deposition Results In Sustained Reduction Of Amyloid Plaque Pathology, Pritam Das, Christophe Verbeeck, Lisa Minter, Paramita Chakrabarty, Kevin Felsenstein, Thomas Kukar, Ghulam Maharvi, Abdul Fauq, Barbara A. Osborne, Todd E. Golde
Barbara A. Osborne
Background: Alzheimer’s disease (AD) is the leading cause of dementia among the elderly. Disease modifying therapies targeting Aβ that are in development have been proposed to be more effective if treatment was initiated prior to significant accumulation of Aβ in the brain, but optimal timing of treatment initiation has not been clearly established in the clinic. We compared the efficacy of transient pharmacologic reduction of brain Aβ with a γ-secretase inhibitor (GSI ) for 1–3 months (M) treatment windows in APP Tg2576 mice and subsequent aging of the mice to either 15M or 18M. Results: These data show that reducing …