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Full-Text Articles in Cell Biology
The Role Of Acetyl-Coa Carboxylase In The Survival Of Trypanosoma Brucei During Infection, Ciara Mcknight
The Role Of Acetyl-Coa Carboxylase In The Survival Of Trypanosoma Brucei During Infection, Ciara Mcknight
All Theses
This master's thesis focuses on how disruption of fatty acid metabolism affects both host adaptation and immune evasion in the deadly eukaryotic parasite, Trypanosoma brucei. In Chapter 1, I review the current literature on African trypanosomiasis, fatty acid synthesis, immune evasion, and lipid metabolism. In Chapter 2, I investigate how disruption of the fatty acid synthesis pathway affects the parasite's ability to evade the host immune defenses. When T. brucei acetyl-CoA carboxylase (TbACC) is knocked down by RNA interference (RNAi), fluid phase and receptor mediated endocytosis pathways are greatly affected, suggesting that fatty acid synthesis is necessary for both endocytic …
Internalization Of F-Actin Monomers Into 3t3 Fibroblasts Via Thermal Inkjet Printing For Investigation Of Cytoskeleton Incorporation And Mechanics, Stephen Shuford
Internalization Of F-Actin Monomers Into 3t3 Fibroblasts Via Thermal Inkjet Printing For Investigation Of Cytoskeleton Incorporation And Mechanics, Stephen Shuford
All Theses
ABSTRACT
We will review the conversion of a standard thermal inkjet printer into a bioprinting system and the effects of printing F-actin monomers with cells. The use of any printing system along with biological material or for biological or medical use has been termed bioprinting. Bioprinting has been used in vascular grafts, scaffold design, gene transfection, micro patterning and many other applications and is very diverse. Specifically we will look at the internalization of F-actin monomers into 3T3 fibroblasts as a result of cell membrane disruption from thermal inkjet printing. If the actin monomers were internalized and then incorporated into …