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Full-Text Articles in Cell Biology
Identifying The Function Of The Calpain Small Subunit In The Mechanics Of Cell Migration, Bingqing Hao
Identifying The Function Of The Calpain Small Subunit In The Mechanics Of Cell Migration, Bingqing Hao
Wayne State University Dissertations
Cell migration plays a vital role in many physiological events including: morphogenesis, wound healing, and immune response. Dysfunctional cell migration results in multiple disease states including chronic inflammation, vascular disease, and tumor metastasis, to name a few. Progress in understanding the mechanism of cell migration had been slow until the turn of the century when rapid technological advances in microscopy and omics burst to the forefront. These advances led to the realization that physical factors (dimensions, fluid shear stress, hydrostatic pressure, compression stress, environmental stiffness, and topography) have profound effects on cell migration. This study of cell mechanics has expanded …
Biophysical And Biochemical Factors In The Cellular Microenvironment; Effects On Cell Migration And Invasion, Shalini Menon
Biophysical And Biochemical Factors In The Cellular Microenvironment; Effects On Cell Migration And Invasion, Shalini Menon
Wayne State University Dissertations
Cellular migration is a vital process central to many physiological events including development, immune surveillance and wound healing. However, migration and invasion are not unique to normal physiology, they are also key determinants in the progression of disease states such as cancer. Given the significance of migration it is important that we understand how the process is regulated intracellularly and the various stimuli that can promote it. Even though the role of biochemical factors in mediating migration has been studied extensively, the role of biophysical factors in modulating migration and invasion is less appreciation. The biochemical and biophysical components of …