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Articles 1 - 6 of 6
Full-Text Articles in Cell Biology
Hexabromocyclododecane Decreases Tumor-Cell-Binding Capacity And Cell-Surface Protein Expression Of Human Natural Killer Cells, Natasha C. Hinkson, Margaret M. Whalen
Hexabromocyclododecane Decreases Tumor-Cell-Binding Capacity And Cell-Surface Protein Expression Of Human Natural Killer Cells, Natasha C. Hinkson, Margaret M. Whalen
Chemistry Faculty Research
Hexabromocyclododecane (HBCD) is a flame retardant that decreases the lytic function of human natural killer (NK) cells. NK cells defend against tumor cells and virally infected cells. Thus, HBCD has the potential to increase cancer incidence and viral infections. NK cells must bind to their targets for lysis to occur. Thus, concentrations of HBCD that decrease lytic function were examined for their ability to alter NK binding to tumor targets. Levels of HBCD that caused a loss of binding function were examined for effects on expression of cell surface proteins needed for binding. NK cells exposed to HBCD for 24 …
Ppar Agonists Down-Regulate The Expression Of Atp10c Mrna During Adipogenesis, A Peretich, Maria Cekanova Ms, Rndr, Phd, S Hurst, Sj Baek, Madhu Dahr
Ppar Agonists Down-Regulate The Expression Of Atp10c Mrna During Adipogenesis, A Peretich, Maria Cekanova Ms, Rndr, Phd, S Hurst, Sj Baek, Madhu Dahr
Faculty Publications and Other Works -- Biochemistry, Cellular and Molecular Biology
No abstract provided.
Ppar Agonists Down-Regulate The Expression Of Atp10c Mrna During Adipogenesis, A Peretich, Maria Cekanova Ms, Rndr, Phd, S Hurst, Sj Baek, Madhu Dahr
Ppar Agonists Down-Regulate The Expression Of Atp10c Mrna During Adipogenesis, A Peretich, Maria Cekanova Ms, Rndr, Phd, S Hurst, Sj Baek, Madhu Dahr
Maria Cekanova MS, RNDr, PhD
No abstract provided.
Tetrabromobisphenol A Has Immunosuppressive Effects On Human Natural Killer Cells, Esther Caroline Kibakaya, Krishna Stephen, Margaret M. Whalen
Tetrabromobisphenol A Has Immunosuppressive Effects On Human Natural Killer Cells, Esther Caroline Kibakaya, Krishna Stephen, Margaret M. Whalen
Chemistry Faculty Research
Human natural killer (NK) cells are lymphocytes that destroy tumor cells, virally-infected cells, and antibody-coated cells. Tetrabromobisphenol A (TBBPA) is used both as a reactive and as an additive flame retardant in a variety of materials and appears to contaminate the environment. TBBPA has been found in human blood samples and if it interferes with NK cell function, this could increase the risk of tumor development and/or viral infection. The present study examines the effects of exposure to various concentrations of TBBPA for 24 hr, 48 hr, and 6 days on the lytic function, tumor-target-binding function, and ATP levels of …
The Role Of Human Endogenous Retroviruses In Renal Cell Carcinoma, Michele D. Tisdale
The Role Of Human Endogenous Retroviruses In Renal Cell Carcinoma, Michele D. Tisdale
Biological Sciences Theses & Dissertations
Human endogenous retroviruses make up approximately 8-9% of the human genome. A number of expressed HERVs, those that are actively transcribing, have been associated with various cancers. Suppression mechanisms that control HERV expression often fail or become more permissive in tissues where expression should be restricted. Previous studies have identified HERV expression in breast cancer tissues, whereas normal tissue HERV expression remained suppressed. In addition, studies of DNA hypermethylation have correlated with the ability to contribute to cancer development. Hypermethylation of several tumor suppressor genes occurs frequently in cancers and alterations in promoter regions could contribute to the development of …
Hexabromocyclododecane Decreases The Lytic Function And Atp Levels Of Human Natural Killer Cells, Natasha C. Hinkson, Margaret M. Whalen
Hexabromocyclododecane Decreases The Lytic Function And Atp Levels Of Human Natural Killer Cells, Natasha C. Hinkson, Margaret M. Whalen
Chemistry Faculty Research
This study investigates the effect of hexabromocyclododecane (HBCD) on the lytic function of human natural killer (NK) cells and on ATP levels in NK cells. NK cells are capable of lysing tumor cells, virally infected cells, and antibody-coated cells. HBCD is a brominated cyclic alkane used primarily as an additive flame retardant. If HBCD interferes with NK cell function, this could increase risk of tumor development and/or viral infection. NK cells were exposed to various concentrations of HBCD for 24 and 48 h and 6 days before determining lytic function and ATP levels. ATP levels and lytic function were also …