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Full-Text Articles in Cell Biology
Modeling Brain Injury: Expression Of Glial Fibrillary Acidic Protein In Stretch-Injured Astrocytes, Lindsey Cooke
Modeling Brain Injury: Expression Of Glial Fibrillary Acidic Protein In Stretch-Injured Astrocytes, Lindsey Cooke
Undergraduate Theses and Capstone Projects
Traumatic brain injury (TBI) is the leading cause of death and disability in individuals under 45. Individuals who survive TBI may be disabled for the rest of their lives and suffer from cognitive, physical, social and financial problems. Following TBI it has been shown that astrocytic gene expression of many proteins, including glial fibrillary acidic protein (GFAP), increases. These “reactive” astrocytes are thought to have both beneficial and detrimental effects on neuronal survival and function. The current study uses an in vitro model of injury which grows astrocytes on deformable silastic membranes to allow for dynamic stretch of cultured cells …