Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Cell Biology
Differential Migration Of Cd4+ And Cd8+ T Cells During An Immune Response, Jacob Parrott
Differential Migration Of Cd4+ And Cd8+ T Cells During An Immune Response, Jacob Parrott
Theses and Dissertations
ABSTRACT
DIFFERENTIAL MIGRATION OF CD4+ AND CD8+ T CELLS DURING AN IMMUNE RESPONSE
by
Jacob Parrott
The University of Wisconsin-Milwaukee, 2018
Under the Supervision of Professor Douglas Steeber
Lymphocyte migration is critical for recognizing pathogenic challenges in a timely manner and generating effective, rapid immune responses. Lymphocyte numbers in secondary lymphoid tissues such as lymph nodes are rapidly and dramatically increased during an immune response. Lymphocytes use specific adhesion molecules and intracellular signaling cascades to migrate and enter secondary lymphoid tissues under resting conditions. It is not clear if the same migration and/or entry pathways are utilized when secondary lymphoid …