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Uncovering Dual Roles For Perk Signaling During Experimentally Induced Pancreatitis, Elena Fazio
Uncovering Dual Roles For Perk Signaling During Experimentally Induced Pancreatitis, Elena Fazio
Electronic Thesis and Dissertation Repository
Pancreatitis is characterized by inappropriate activation of digestive enzyme
precursors, or zymogens, local and systemic inflammation, dysregulation of
cellular calcium (Ca2+), and induction of the unfolded protein response (UPR).
The UPR consists of three distinct pathways all of which are activated during
pancreatitis. However, the molecular roles of each remain unclear. The
protein kinase RNA (PKR)-like ER kinase (PERK) pathway reduces general
protein translation by phosphorylating eIF2!, and is activated within minutes
of initiating pancreatic damage. Microarray analysis carried out by our lab
revealed robust upregulation of the PERK pathways members Activating
Transcription Factor (ATF) 3 and stanniocalcin (STC) 2. …