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Articles 1 - 7 of 7
Full-Text Articles in Cell and Developmental Biology
Sexually Dimorphic Alterations In Brain Morphology Of Astrocyte Conditional System Xc- Knockout Mice, Gabrielle Emily Samulewicz
Sexually Dimorphic Alterations In Brain Morphology Of Astrocyte Conditional System Xc- Knockout Mice, Gabrielle Emily Samulewicz
Honors Capstone Projects - All
Astrocytes play a vital role in orchestrating the precise brain wiring that occurs during development and are essential for maintaining homeostasis into adulthood. The cystine/glutamate antiporter, system xc-, in the central nervous system is especially abundant in astrocytes and itself is known to contribute importantly to the basal extracellular glutamate concentration as well as the intracellular and extracellular glutathione levels, either of which, if perturbed, could alter brain development and/or contribute to degeneration. Thus, to determine whether loss of astrocyte system xc- might alter brain morphology, I studied a conditional astrocyte system xc- knockout mouse (AcKO). Tissue was harvested from …
Progesterone Signaling In Mouse Oocyte Development Via The Pgrmc1 And Pgrmc2 Receptors And The Pairbp1 Protein, Amanda M. Catchings
Progesterone Signaling In Mouse Oocyte Development Via The Pgrmc1 And Pgrmc2 Receptors And The Pairbp1 Protein, Amanda M. Catchings
Honors Capstone Projects - All
There are thought to be many different causes that can lead to the development of infertility in females. Many of the causes for this condition present themselves before birth, which can predetermine a woman’s fertility capability before she is even born. The complex process of germ cell development possesses possibilities for error and malfunction that can have permanent, lasting effects on a developing fetus. The process of oocyte development is initiated when primordial germ cells migrate to the embryotic gonad and begin dividing mitotically. As mitosis proceeds, the process of cytokinesis does not go to completion, which maintains the cells …
A Novel Therapeutic Approach In Breast And Hematopoietic Cancers: Inhibition Of Sh2-Domain Containing Inositol 5' Phosphatase (Ship), Amamda Balch
Honors Capstone Projects - All
Aberrant hyperactivation of the phosphatidylinositol 3-kinase (PI3K) cell-signaling pathway, one of the most prominent cell growth, proliferation and survival pathways in the human body, has been observed in many forms of cancer. Upon deregulation, this pathway can facilitate the evasion of programmed cell death, the stimulation of autonomous growth, and the evasion of regular growth-inhibitory signals. While it was initially believed that the dephosphorylation activity of lipid phosphatases served to counteract the pathway by hydrolyzing phosphatidylinositol(3,4,5)trisphosphate (PtdIns(3,4,5)P3) to phosphatidylinositol(4,5)bisphosphate (PtdIns(4,5)P2), emerging evidence suggests that SH2-domain containing inositol 5’ phosphatase 1 and 2 (SHIP1/2) may in fact …
Analyzing The Roles Of Scl And Gata3 In Zebrafish Spinal Cord Interneuron Specification And Function, Kadiah Oyah Kamara
Analyzing The Roles Of Scl And Gata3 In Zebrafish Spinal Cord Interneuron Specification And Function, Kadiah Oyah Kamara
Honors Capstone Projects - All
My project focuses on the V2 cells of the zebrafish spinal cord. The V2 cells are an unusual class of spinal cells because they all originate from molecularly indistinguishable p2 progenitor cells in the spinal cord. However, as these cells become post-mitotic and differentiate, they start to express different transcription factor genes that allow them to initially develop into two sets of molecularly distinct cells. As differentiation continues, at least one more class of molecularly distinct cells develops. Just as in other vertebrates, in zebrafish the V2 cells differentiate into at least two functionally distinct classes of cells, specifically, the …
Effect Of Combining Bcl-2 Inhibition And Radiation On Apoptotic Cell Death In Human Breast Cancer Cell Lines As Determined By Clonogenic Assay And Western Blots, Amari Sasha Howard
Effect Of Combining Bcl-2 Inhibition And Radiation On Apoptotic Cell Death In Human Breast Cancer Cell Lines As Determined By Clonogenic Assay And Western Blots, Amari Sasha Howard
Honors Capstone Projects - All
Cancer is a group of diseases characterized by abnormal control of cell growth and cell survival. Current treatment for cancer employs a combination of modalities including surgery, radiation, chemotherapeutic drugs, and immunotherapy. Our lab focuses on personalized medicine and treatments that can specifically target molecular features of a tumor as presented by the particular patient being treated. Cancers often exhibit an over-expression or under-expression of certain proteins that play a large role in regulating the process of apoptosis, which is programmed cell death. This study focuses on proposing drug treatment for cancer that is personalized in that it targets a …
Role Of Progesterone Receptors In Neonatal Ovary Development, Marta N. Dzyadyk
Role Of Progesterone Receptors In Neonatal Ovary Development, Marta N. Dzyadyk
Honors Capstone Projects - All
In female mammals, proper oocyte development is a vital prerequisite for future gamete viability and fertility. This development of oocytes, known as oogenesis, begins with the migration of primordial germ cells to the genital ridge of the early embryo, where multiple rounds of mitotic division occur without complete cytokinesis. The result is temporary cyst morphology. Cyst breakdown is a crucial process in the next developmental stage, resulting in formation of the single oocytes which will grow in follicles surrounded by granulosa cells and eventually develop into eggs. These aspects of embryogenesis are conserved across multiple species, including Drosophila, mice, and …
The Expression Pattern Of The Xenopus Laevis Rod-Derived Cone Viability Factor1 (Rdcvf1), Vera Osafo
The Expression Pattern Of The Xenopus Laevis Rod-Derived Cone Viability Factor1 (Rdcvf1), Vera Osafo
Honors Capstone Projects - All
In the United States alone, more than one million people are blind. One of the leading causes of blindness is the retinal disease, Retinitis Pigmentosa (RP). RP is a heterogeneous group of inherited disorders characterized by the initial loss of rod photoreceptors. Approximately 100,000 people in the United States and 1.5 million people worldwide are affected by RP. Unfortunately, there is no cure. In humans with RP, it is known that the loss of rod photoreceptors leads to degeneration of cones. Rods photoreceptors are responsible for vision under low light conditions and cone photoreceptors are required for color vision and …