Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Genetics and Genomics (4)
- Biochemistry, Biophysics, and Structural Biology (3)
- Cell and Developmental Biology (3)
- Bioinformatics (2)
- Biology (2)
-
- Cell Biology (2)
- Computational Biology (2)
- Genetics (2)
- Laboratory and Basic Science Research (2)
- Microbiology (2)
- Molecular Biology (2)
- Biochemistry (1)
- Biomaterials (1)
- Biomedical Engineering and Bioengineering (1)
- Cancer Biology (1)
- Chemicals and Drugs (1)
- Engineering (1)
- Environmental Microbiology and Microbial Ecology (1)
- Food Biotechnology (1)
- Food Science (1)
- Genomics (1)
- Immunology and Infectious Disease (1)
- International and Community Nutrition (1)
- Medical Sciences (1)
- Medicine and Health Sciences (1)
- Molecular Genetics (1)
- Molecular, Cellular, and Tissue Engineering (1)
- Nanoscience and Nanotechnology (1)
- Keyword
-
- Cell (2)
- Protein (2)
- Agriculture (1)
- Angiogenic (1)
- Antigen (1)
-
- Awesome (1)
- Beta-2-microglobulin (1)
- Biochemistry (1)
- Biodegradable (1)
- Bioinformatics (1)
- Biology (1)
- Biosensor (1)
- Bouvier (1)
- CRISPR (1)
- CRISPR-Cas (1)
- Cheng (1)
- Class I MHC (1)
- Computational biology (1)
- FRET (1)
- Fluorophore (1)
- Force (1)
- GFP (1)
- Gene editing (1)
- HLA-B*0801-fos (1)
- Histocompatibility (1)
- Immune (1)
- In Vitro (1)
- International (1)
- Kenneth (1)
- Limitation (1)
Articles 1 - 5 of 5
Full-Text Articles in Biotechnology
Alterations Of The Gut Mycobiome In Patients With Ms - A Bioinformatic Approach, Saumya Shah
Alterations Of The Gut Mycobiome In Patients With Ms - A Bioinformatic Approach, Saumya Shah
Honors Scholar Theses
The mycobiome is the fungal component of the gut microbiome and is implicated in several autoimmune diseases. However, its role in multiple sclerosis (MS) has not been studied. We performed descriptive and formal statistical tests using the R language to characterize the gut mycobiome in people with MS (pwMS) and healthy controls. We found that the microbiome composition of multiple sclerosis patients is different from healthy people. The mycobiome had significantly higher alpha diversity and inter-subject variation in pwMS than controls. Additionally, Saccharomyces and Aspergillus were over-represented in pwMS. Different mycobiome profiles, defined as mycotypes, were associated with different bacterial …
Impact Of Angiogenic And Osteogenic Factors In The Presence Of Biodegradable Piezoelectric Films, Jayla Millender
Impact Of Angiogenic And Osteogenic Factors In The Presence Of Biodegradable Piezoelectric Films, Jayla Millender
Honors Scholar Theses
One of the most common causes of bone graft rejection is lack of a vascular network connecting the graft to the existing native tissue – allowing for nutrient flow. Under current grafting techniques, the existing blood vessel network in the patient slowly invades the implant in order to supply the injured site with its necessary nutrients. The purpose of this research is to determine if a synthetic bone graft with a stable microvascular network can be developed in vitro. I hypothesize that the use of indirect angiogenic factors such as sonic hedgehog homolog and hypoxia-inducible factor-1 in combination with the …
Single-Fluorophore Sensors For Mechanical Force In Living Cells, Sarah Kricheff
Single-Fluorophore Sensors For Mechanical Force In Living Cells, Sarah Kricheff
Honors Scholar Theses
Mechanotransduction is the process by which a mechanical stimulus is converted to a cellular signal. This process is heavily influential of cell morphology, differentiation, and behavior. However, altered levels of mechanical stimuli are also found in many pathological contexts. For example, cancerous cells have stiffer surrounding tissue than healthy cells, and research suggests that this alters cell behavior and promotes metastasis. Despite these findings, the cellular processes behind these signaling alterations remain widely unknown. Understanding these cascades is critical, as involved proteins can give us a deeper understanding of the role of mechanotransduction, and certain proteins can potentially be targeted …
An Analysis Of Crispr-Cas Gene Editing In Agriculture, Ashley Laliberte
An Analysis Of Crispr-Cas Gene Editing In Agriculture, Ashley Laliberte
Honors Scholar Theses
The CRISPR-Cas system is a promising form of gene editing, especially for the agriculture industry. The ability to make single-nucleotide edits within a gene of interest, without the need to introduce foreign DNA, is a powerful tool for designing healthier and more efficient crops and food animals. This system provides opportunity for increased nutritional value, decreased food waste, and more economically and environmentally sustainable food production. Though this biotechnology is facing mechanistic limitations due to off-target effects and inefficient homology-directed repair, vast improvements have already been made to improve its efficacy. The CRISPR-Cas system is already the most advanced form …
In Vitro Expression And Purification Of Class I Mhc Molecules, Loi Cheng
In Vitro Expression And Purification Of Class I Mhc Molecules, Loi Cheng
Honors Scholar Theses
The major histocompatibility complex (MHC) is a gene family responsible for many critical functions of the immune system in most vertebrates. The MHC consists of three classes differentiated by their structure and function, and MHC class I encodes antigen binding proteins as well as chaperone and accessory proteins such as tapasin. The purpose of this project is to reconstitute several human MHC class I molecules in their peptide-filled and peptide-deficient forms, and to purify these proteins for biochemical study. The expressed proteins include wild type and mutant variants of the fusion protein human leukocyte antigen HLA-B*0801-fos, and human beta-2-microglobulin (β2m). …