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Articles 1 - 9 of 9
Full-Text Articles in Biology
Fungi In Flux | Designing Regenerative Materials And Products With Mycelium, Arvind Bhallamudi
Fungi In Flux | Designing Regenerative Materials And Products With Mycelium, Arvind Bhallamudi
Masters Theses
As the world grapples with the escalating crisis of climate threats and environmental degradation, this research delves into the synergistic potential of design and biology, developing safe and sustainable materials for applications in prototyping, furniture and interior design. Harnessing the power of a unique organism - fungi, the study proposes an accessible, efficient, and resilient material resource system. It utilizes local waste streams and mycelium (the vegetative part of fungi) to grow functional structures. An experimental and small-scale protocol is modeled by testing bio-fabrication and bio-printing methods. The composites' performance qualities and characteristics are evaluated through mechanical testing and a …
In Vitro And In Vivo Response To A Novel Borophosphate Bioactive Glass, Nada Abokefa
In Vitro And In Vivo Response To A Novel Borophosphate Bioactive Glass, Nada Abokefa
Masters Theses
"Bioactive glasses have been widely used in several biomedical and tissue engineering applications since the late 1960s. Numerous families of bioactive glasses have emerged over the years, with each having its own advantage and disadvantage. One concern common to all families is that most bioactive glasses create a basic or acidic environment when degraded and, therefore, are toxic for cells. Recently, there has been an increased interest in borophosphate bioactive glass (BPBGs) because of their neutral pH, release of therapeutic ions, and biodegradable properties. Despite the growing interest, there is little reported on the bioactivity of BPBGs. The biological effects …
Microenvironment Regulates Fusion Of Breast Cancer Cells, Peiran Zhu
Microenvironment Regulates Fusion Of Breast Cancer Cells, Peiran Zhu
Masters Theses
Fusion of cancer cells has been observed in tumors for more than a century and is thought to contribute to tumor development and drug resistance. The low frequency of cell fusion events and the instability of fused cells have hindered our ability to understand the molecular mechanisms that govern cell fusion. We have developed a patterned gel system that can isolate cell fusion events and we demonstrate that several breast cancer cell lines can fuse into multinucleated giant cells in vitro, and the initiation and longevity of fused cells can be regulated solely by biophysical factors. Dynamically tuning the adhesive …
Fluid Flow In A Krogh Cylinder: A Model For A Single Capillary And Surrounding Tissue, Xianjie Qiu
Fluid Flow In A Krogh Cylinder: A Model For A Single Capillary And Surrounding Tissue, Xianjie Qiu
Masters Theses
"A model describing the flow of plasma from the capillaries to the interstitial space in the extravascular tissue and back into the capillaries is constructed and solved. The flow through the tissue or the interstitial spaces is described by the Brinkman equation for porous medium, modified to account for the presence of cells considered as spheres. The flow of blood through the capillaries is considered to be that of a Newtonian fluid. The flow between capillary and tissue is coupled by the permeability of the capillary wall. The nature of flow and its magnitude was found to be highly dependent …
Classification Of Basal Cell Carcinoma Using Telangiectatic Vessels And Machine Learning, Hemanth Yadav Aradhyula
Classification Of Basal Cell Carcinoma Using Telangiectatic Vessels And Machine Learning, Hemanth Yadav Aradhyula
Masters Theses
“Basal cell carcinoma (BCC) is one of the most common types of skin cancer in the United States. Early detection of BCC by noninvasive techniques can decrease delay in treatment and save cost. A recent study estimated that 5.4 million cases of non-melanocytic skin cancer (NMSC) occur each year in the US. BCC accounts for 50% of NMSC cases. Telangiectasia, which appears in most BCCs is an important feature for identification of BCC for an automatic diagnostic system. In this thesis, three methods for detection of telangiectasia present in dermoscopy lesion image (DI) were proposed. Detected telangiectasia in DI was …
Combination Of Bmp-2 And Relaxin To Induce Osteogenesis In Vivo, Sahitya Injamuri
Combination Of Bmp-2 And Relaxin To Induce Osteogenesis In Vivo, Sahitya Injamuri
Masters Theses
"Bone grafts are a common procedure for treating craniofacial injuries such as trauma, surgery, and reconstruction. Autografts and allografts have limitations which encourages the use of synthetic bone grafts. While synthetic bone grafts, such as hydroxyapatite (HA) microspheres, are advantageous for their cost and reproducibility, they lack the cells and growth factors needed for proper osteoinduction. Bone morphogenetic protein-2 (BMP-2) has been shown to increase the osteoinduction of grafts but the effective dose is above physiological levels and causes undesired effects on the body. Relaxin has been shown to enhance BMP-2's ability to induce bone formation in vitro and thus …
Phytoforensics Tools: The Degradation And Detection Of Chlorinated Solvents In Integrated Systems, Tommy J. Goodwin Jr.
Phytoforensics Tools: The Degradation And Detection Of Chlorinated Solvents In Integrated Systems, Tommy J. Goodwin Jr.
Masters Theses
"Due to decades of mismanaged pollutants entering groundwater, subsurface pollution of various compounds has become a widespread challenge. Chlorinated solvents are the most common groundwater contaminants that persist in aquifers, and remediation of these wide-spread plumes is difficult. Bioremediation, permeable reactive barriers, and phytoremediation are remedial technologies that have been developed and applied to chlorinated solvents in groundwater systems. This study integrates these technologies in different combinations to demonstrate the remediation potential of this approach. Zerovalent iron (ZVI) and bioaugmentation with a Dehalococcoides sp. (DHC) culture were applied separately and in combination for degradation of perchloroethene (PCE). Salix pentandra were …
Promoting Extracellular Matrix Crosslinking In Synthetic Hydrogels, Marcos M. Manganare
Promoting Extracellular Matrix Crosslinking In Synthetic Hydrogels, Marcos M. Manganare
Masters Theses
The extracellular matrix (ECM) provides mechanical and biochemical support to tissues and cells. It is crucial for cell attachment, differentiation, and migration, as well as for ailment-associated processes such as angiogenesis, metastases and cancer development. An approach to study these phenomena is through emulation of the ECM by synthetic gels constructed of natural polymers, such as collagen and fibronectin, or simple but tunable materials such as poly(ethylene glycol) (PEG) crosslinked with short peptide sequences susceptible to digestion by metalloproteases and cell-binding domains. Our lab uses PEG gels to study cell behavior in three dimensions (3D). Although this system fosters cell …
Healing Of Bone Defects In A Rodent Calvarial Defect Model Using Strong Porous Bioactive Glass (13-93) Scaffolds, Yinan Lin
Masters Theses
"The main objective of this project was to evaluate the capacity of strong porous silicate (13-93) bioactive glass scaffolds prepared by a robocasting technique to regenerate bone and stimulate angiogenesis in a rat calvarial defect model. The scaffolds were created with the same grid-like microstructure but in a variety of formulations: (i) as-fabricated, (ii) pretreated in an aqueous phosphate solution to convert the glass surface to hydroxyapatite, (iii) loaded with bone morphogenetic protein-2 (BMP2) (1 µg per scaffold), and (iv) doped with copper (0.4-2.0 wt. % CuO). When compared to the as-fabricated scaffolds, the pretreated scaffolds enhanced bone regeneration at …