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Articles 1 - 30 of 72
Full-Text Articles in Biology
Recent Advances In Centrifugal Spinning And Their Applications In Tissue Engineering, Shaik Merkatur Hakim Marjuban, Musfira Rahman, Syeda Sharmin Duza, Mohammad Boshir Ahmed, Dinesh K Patel, Md Saifur Rahman, Karen Lozano
Recent Advances In Centrifugal Spinning And Their Applications In Tissue Engineering, Shaik Merkatur Hakim Marjuban, Musfira Rahman, Syeda Sharmin Duza, Mohammad Boshir Ahmed, Dinesh K Patel, Md Saifur Rahman, Karen Lozano
Journal Articles
Over the last decade, researchers have investigated the potential of nano and microfiber scaffolds to promote wound healing, tissue regeneration, and skin protection. The centrifugal spinning technique is favored over others due to its relatively straightforward mechanism for producing large quantities of fiber. Many polymeric materials have yet to be investigated in search of those with multifunctional properties that would make them attractive in tissue applications. This literature presents the fundamental process of fiber generation, and the effects of fabrication parameters (machine, solution) on the morphologies such as fiber diameter, distribution, alignment, porous features, and mechanical properties. Additionally, a brief …
Energy Neutral: The Human Foot And Ankle Subsections Combine To Produce Near Zero Net Mechanical Work During Walking, Kota Z. Takahashi, Kate Worster, Dustin A. Bruening
Energy Neutral: The Human Foot And Ankle Subsections Combine To Produce Near Zero Net Mechanical Work During Walking, Kota Z. Takahashi, Kate Worster, Dustin A. Bruening
Journal Articles
The human foot and ankle system is equipped with structures that can produce mechanical work through elastic (e.g., Achilles tendon, plantar fascia) or viscoelastic (e.g., heel pad) mechanisms, or by active muscle contractions. Yet, quantifying the work distribution among various subsections of the foot and ankle can be difficult, in large part due to a lack of objective methods for partitioning the forces acting underneath the stance foot. In this study, we deconstructed the mechanical work production during barefoot walking in a segment-by-segment manner (hallux, forefoot, hindfoot, and shank). This was accomplished by isolating the forces acting within each foot …
Omura’S Whales (Balaenoptera Omurai) Off Northwest Madagascar: Ecology, Behaviour And Conservation Needs, Salvatore Cerchio, Boris Andrianantenaina, Alec R. Lindsay, Melinda Rekdahl, Norbert Andrianarivelo, Tahina Rasoloarijao
Omura’S Whales (Balaenoptera Omurai) Off Northwest Madagascar: Ecology, Behaviour And Conservation Needs, Salvatore Cerchio, Boris Andrianantenaina, Alec R. Lindsay, Melinda Rekdahl, Norbert Andrianarivelo, Tahina Rasoloarijao
Journal Articles
No abstract provided.
New Collections Of Freshwater Crabs From Northern Madagascar, With The Description Of A New Species Of Foza Reed & Cumberlidge, 2006 (Brachyura, Potamonautidae), And Comments On Their Conservation Status, Neil Cumberlidge, Sebastian Klaus, Kirstin S. Meyer, Jennifer C. Kroppin
New Collections Of Freshwater Crabs From Northern Madagascar, With The Description Of A New Species Of Foza Reed & Cumberlidge, 2006 (Brachyura, Potamonautidae), And Comments On Their Conservation Status, Neil Cumberlidge, Sebastian Klaus, Kirstin S. Meyer, Jennifer C. Kroppin
Journal Articles
No abstract provided.
Multi-Locus Phylogeny Of The Afrotropical Freshwater Crab Fauna , Savel Regan Daniels Phd, E E. Phiri, Sebastian Klaus Phd, C Albrecht, Neil Cumberlidge
Multi-Locus Phylogeny Of The Afrotropical Freshwater Crab Fauna , Savel Regan Daniels Phd, E E. Phiri, Sebastian Klaus Phd, C Albrecht, Neil Cumberlidge
Journal Articles
No abstract provided.
A Molecular Genetic Assessment Of Sex Ratios From Pre- Fledged Juvenile And Migrating Adult Common Loons (Gavia Immer), Alec R. Lindsay
A Molecular Genetic Assessment Of Sex Ratios From Pre- Fledged Juvenile And Migrating Adult Common Loons (Gavia Immer), Alec R. Lindsay
Journal Articles
We used a polymerase chain reaction (PCR)-based sex identification technique to evaluate the sex ratios of pre-fledged juvenile Common Loons (Gavia immer) from three breeding populations in northern Michi- gan and northern Wisconsin, and of dead adult Common Loons migrating through Lake Huron. Results of these analyses show that more juvenile males than females fledged from all three breeding populations, although none of these biases differed significantly from parity. The sex ratio of migratory adults was at parity. No parental or territory quality indicators were significantly associated with the sex of chicks fledged from one intensely studied northern Michigan population …
Quantification Of Protoporphyrin Ix Accumulation In Glioblastoma Cells – A New Technique, John E Lawrence
Quantification Of Protoporphyrin Ix Accumulation In Glioblastoma Cells – A New Technique, John E Lawrence
Journal Articles
5-Aminolevulinic Acid (5-ALA) is a precursor of heme synthesis. A metabolite, protoporphyrin IX (PpIX), selectively accumulates in neoplastic tissue including glioblastoma. Presurgical administration of 5-ALA forms the basis of fluorescence-guided resection (FGR) of glioblastoma (GBM) tumors. However, not all gliomas accumulate sufficient quantities of PpIX to fluoresce, thus limiting the utility of FGR. We therefore developed an assay to determine cellular and pharmacological factors that impact PpIX fluorescence in GBM. This assay takes advantage of a GBM cell line engineered to express yellow fluorescent protein. Methods. The human GBM cell line U87MG was transfected with a YFP expression vector. After …
Changes During Late-Stage Embryonic Development From Egg-Juvenile To Free-Living Hatchling Crab , J Xue, Y Liu, Neil Cumberlidge, H Wu
Changes During Late-Stage Embryonic Development From Egg-Juvenile To Free-Living Hatchling Crab , J Xue, Y Liu, Neil Cumberlidge, H Wu
Journal Articles
No abstract provided.
Glioblastoma Derived Exosomes Induce Apoptosis In Cytotoxic T Cells Through A Fas Ligand Mediated Mechanism , Keith Z. Sabin, Richard A. Rovin, Johnathan Lawrence, Robert J. Belton Jr, Robert J. Winn
Glioblastoma Derived Exosomes Induce Apoptosis In Cytotoxic T Cells Through A Fas Ligand Mediated Mechanism , Keith Z. Sabin, Richard A. Rovin, Johnathan Lawrence, Robert J. Belton Jr, Robert J. Winn
Journal Articles
INTRODUCTION: Glioblastoma multiforme deploy s a number of weapons to thwart the immune system. Within the tumor microenvironment, cytotoxic T cells fall victim to Fas ligand (FasL) induced apoptosis. In prostate and colorectal cancer, exosomes can mediate this FasL induced T cell apoptosis. Exosomes are tiny, membrane bound vesicles that are released from a cell. They contain functional mRNA and protein and have cell surface molecules representative of their parent cell. It is not known if GBM derived exosomes can also mediate FasL triggered apoptosis. In this study, the role of tumor derived exosomes as the delivery vehicle for FasL …
Leptin Promotes Glioblastoma , Johnathan Lawrence, Nicholas J. Cook, Richard A. Rovin, Robert J. Winn
Leptin Promotes Glioblastoma , Johnathan Lawrence, Nicholas J. Cook, Richard A. Rovin, Robert J. Winn
Journal Articles
The hormone leptin has a variety of functions. Originally known for its role in satiety and weight loss, leptin more recently has been shown to augment tumor growth in a variety of cancers. Within gliomas, there is a correlation between tumor grade and tumor expression of leptin and its receptor. This suggests that autocrine signaling within the tumor microenvironment may promote the growth of high-grade gliomas. Leptin does this through stimulation of cellular pathways that are also advantageous for tumor growth and recurrence: antiapoptosis, proliferation, angiogenesis, and migration. Conversely, a loss of leptin expression attenuates tumor growth. In animal models …
The Freshwater Crabs Of Ethiopia, Northeastern Africa, With The Description Of A New Potamonautes Cave Species , Neil Cumberlidge, Paul F. Clark
The Freshwater Crabs Of Ethiopia, Northeastern Africa, With The Description Of A New Potamonautes Cave Species , Neil Cumberlidge, Paul F. Clark
Journal Articles
No abstract provided.
Effects Of Ss3-Adrenergic Receptor Agonist On Gene Expression Of Leptin In Glioblastoma , Johnathan Lawrence, Nicholas J. Cook, Richard A. Rovin, Robert J. Belton Jr, Robert J. Winn
Effects Of Ss3-Adrenergic Receptor Agonist On Gene Expression Of Leptin In Glioblastoma , Johnathan Lawrence, Nicholas J. Cook, Richard A. Rovin, Robert J. Belton Jr, Robert J. Winn
Journal Articles
In the 25 years since temozolomide entered phase I clinical trials, few new primary or adjuvant therapies have been developed for the treatment of glioblastoma multiforme (GBM) tumors. Our laboratory has been exploring novel methods for the treatment of GBMs. Recent studies indicate that the expression of the hormone leptin and its receptor (OBR) increases in gliomas and positively correlates with the malignancy of the tumor. Interestingly, ß3-adrenergic receptor agonists are known to decrease leptin expression in adipocytes but have not been examined in GBM cells. We hypothesized that b3-adrenergic agonists downregulate the expression of leptin and its receptor. In …
Implications Of Bias In Conservation Research And Investment For Freshwater Species , William Darwall, R Holland, K Smith, D Allen, E Brooks, V Katarya, C Pollock, Y Shi, Viola Clausnitzer, Neil Cumberlidge, A Cuttelod, K D. Dijkstra, M Diop, N Garcia, M Seddon, P Skelton, J Snoeks, D Tweddle, Jc Vie
Implications Of Bias In Conservation Research And Investment For Freshwater Species , William Darwall, R Holland, K Smith, D Allen, E Brooks, V Katarya, C Pollock, Y Shi, Viola Clausnitzer, Neil Cumberlidge, A Cuttelod, K D. Dijkstra, M Diop, N Garcia, M Seddon, P Skelton, J Snoeks, D Tweddle, Jc Vie
Journal Articles
No abstract provided.
"Evidence That Salt Water May Not Be A Barrier To The Dispersal Of Asian Freshwater Crabs" , Lara J. Esser, Neil Cumberlidge
"Evidence That Salt Water May Not Be A Barrier To The Dispersal Of Asian Freshwater Crabs" , Lara J. Esser, Neil Cumberlidge
Journal Articles
No abstract provided.
Glioblastoma Derived Exosomes Contribute To Tumor Immune Evasion , Keith Z. Sabin, Danny Lebert, Vanessa Thibado, Richard A. Rovin, Johnathan Lawrence, Robert J. Winn
Glioblastoma Derived Exosomes Contribute To Tumor Immune Evasion , Keith Z. Sabin, Danny Lebert, Vanessa Thibado, Richard A. Rovin, Johnathan Lawrence, Robert J. Winn
Journal Articles
Glioblastoma multiforme (GBM) is the most frequent and lethal primary brain tumor in adults. Despite intense biomedical research, the median survival after diagnosis is 15 months. One factor contributing to this poor prognosis is the immune protection afforded by the tumor microenvironment. Tumors have a diverse repertoire of immune-evasive techniques. One method of evasion not well explored is the release of tumor-derived exosomes. Exosomes are tiny membrane-bound vesicles of endocytic origin that contain viable mRNA and functional proteins that can affect the physiology of recipient cells. Exosome release has been reported for numerous cancer types, including GBM. Exosomes from colon …
Β3-Adrenergic Agonists Mimic Eustress Response And Reduce Leptin-Mediated Proliferation In A Gbm Cell Line , Johnathan Lawrence, Nicholas J. Cook, Richard A. Rovin, Robert J. Winn
Β3-Adrenergic Agonists Mimic Eustress Response And Reduce Leptin-Mediated Proliferation In A Gbm Cell Line , Johnathan Lawrence, Nicholas J. Cook, Richard A. Rovin, Robert J. Winn
Journal Articles
A great deal of mental stress, depression, and anxiety often overwhelm cancer patients; those diagnosed with glioblastoma multiforme (GBM) are no exception. Different types of stress invariably impact what has been termed “the brain-adipocyte BDNF/leptin axis” (Dr. Cao and colleagues of the Comprehensive Cancer Center at The Ohio State University). For example, eustress (good stress) and distress (bad stress) both lead to increased sympathetic activity and adrenal gland stimulation, yet eustress reduces leptin levels and attenuates tumor growth while distress increases leptin levels and augments tumor growth. Complicating matters in GBM is that leptin and its receptor are expressed at …
"A Revision Of The Freshwater Crabs Of Lake Kivu, East Africa." , Neil Cumberlidge, Kirstin S. Meyer
"A Revision Of The Freshwater Crabs Of Lake Kivu, East Africa." , Neil Cumberlidge, Kirstin S. Meyer
Journal Articles
No abstract provided.
" Diversity, Endemism, And Conservation Of The Freshwater Crabs Of China" , Neil Cumberlidge, Peter Kl Ng, Darren Cj Yeo, Tohru Naruse, Kirstin S. Meyer, Lara J. Esser
" Diversity, Endemism, And Conservation Of The Freshwater Crabs Of China" , Neil Cumberlidge, Peter Kl Ng, Darren Cj Yeo, Tohru Naruse, Kirstin S. Meyer, Lara J. Esser
Journal Articles
No abstract provided.
Expression Of Hcmv Ie1 In The U87mg Cell Line Augments Resistance To Temozolomide , Richard A. Rovin, Johnathan Lawrence, Justin J. Segula, Robert J. Winn
Expression Of Hcmv Ie1 In The U87mg Cell Line Augments Resistance To Temozolomide , Richard A. Rovin, Johnathan Lawrence, Justin J. Segula, Robert J. Winn
Journal Articles
INTRODUCTION: Human cytomegalovirus (HCMV) DNA and protein are found in gliomas but not in normal brain or other primary brain tumors. The role of HCMV infection in glioma biology is unclear. While it is unlikely that HCMV infection causes glioma, viral proteins might impart a proliferative and antiapoptotic phenotype that confers a survival advantage. Does this oncomodulation translate into a clinically relevant effect in glioma cells? To answer this question, we compared the response of the U87IE1 and U87MG malignant glioma cell lines to temozolomide. U87IE1 cells are U87MG cells that have been genetically engineered to produce HCMV IE1 protein. …
First Report Of The Developmental Changes Inside The Eggs Of The Chinese Freshwater Crab , J Xue, Y Liu, Neil Cumberlidge, H X. Wu
First Report Of The Developmental Changes Inside The Eggs Of The Chinese Freshwater Crab , J Xue, Y Liu, Neil Cumberlidge, H X. Wu
Journal Articles
No abstract provided.
"First Report Of Developmental Changes Inside The Eggs Of The Chinese Freshwater Crab, Sinopotamon Yangtsekiense Bott, 1967, With Comments On Its Evolutionary Significance" , J Xue, Y Liu, Neil Cumberlidge, H X. Wu
"First Report Of Developmental Changes Inside The Eggs Of The Chinese Freshwater Crab, Sinopotamon Yangtsekiense Bott, 1967, With Comments On Its Evolutionary Significance" , J Xue, Y Liu, Neil Cumberlidge, H X. Wu
Journal Articles
No abstract provided.
"A Redescription Of Potamonautes Loveni, A Medically Important Feshwater Crab From Western Kenya And Eastern Uganda, East Africa" , Neil Cumberlidge, Paul F. Clark
"A Redescription Of Potamonautes Loveni, A Medically Important Feshwater Crab From Western Kenya And Eastern Uganda, East Africa" , Neil Cumberlidge, Paul F. Clark
Journal Articles
No abstract provided.
The Impact And Shortfall Of Conservation On The Status Of The World's Vertebrates , M Hoffmann, C Hilton-Taylor, A Angulo, Monica Bohm Phd, Shm Bbutchart, K E. Carpenter, J Chanson, B Collen, N A. Cox, Neil Cumberlidge
The Impact And Shortfall Of Conservation On The Status Of The World's Vertebrates , M Hoffmann, C Hilton-Taylor, A Angulo, Monica Bohm Phd, Shm Bbutchart, K E. Carpenter, J Chanson, B Collen, N A. Cox, Neil Cumberlidge
Journal Articles
No abstract provided.
"An Extra Embryonic Phase In The True Freshwater Crab Sinopotamon Yangtsekiense Bott" , H X. Wu, J Z. Xue, Neil Cumberlidge
"An Extra Embryonic Phase In The True Freshwater Crab Sinopotamon Yangtsekiense Bott" , H X. Wu, J Z. Xue, Neil Cumberlidge
Journal Articles
No abstract provided.
Two New Species Of Freshwater Crabs From Mt. Elgon, East Africa With A Redescription Of Potamonautes Niloticus And Notes On Their Natural History" , Neil Cumberlidge, Paul F. Clark
Two New Species Of Freshwater Crabs From Mt. Elgon, East Africa With A Redescription Of Potamonautes Niloticus And Notes On Their Natural History" , Neil Cumberlidge, Paul F. Clark
Journal Articles
No abstract provided.
An Extra Embryonic Phase In The True Freshwater Crab Sinopotamon Yangtsekiense , H X. Wu, J Xue, Neil Cumberlidge
An Extra Embryonic Phase In The True Freshwater Crab Sinopotamon Yangtsekiense , H X. Wu, J Xue, Neil Cumberlidge
Journal Articles
No abstract provided.
A Discourse On The Public Nature Of Research In Contemporary Life Science: A Law-Policy Proposal To Promote The Public Nature Of Science In An Era Of Academia-Industry Integration, Michael J. Malinowski
A Discourse On The Public Nature Of Research In Contemporary Life Science: A Law-Policy Proposal To Promote The Public Nature Of Science In An Era Of Academia-Industry Integration, Michael J. Malinowski
Journal Articles
This article addresses the impact of integration of academia, industry, and government on the public nature of research. The article concludes that, while the integration has benefited science immensely, regulatory measures should be taken to restore the public nature of research in an age of integration.
"A Revision Of The Freshwater Crabs Of Mt Kenya And The Aberdare Mountains, Kenya, East Africa" , Neil Cumberlidge
"A Revision Of The Freshwater Crabs Of Mt Kenya And The Aberdare Mountains, Kenya, East Africa" , Neil Cumberlidge
Journal Articles
No abstract provided.
"A New Species Of Foza Reed & Cumberlidge, 2006, From Northern Madagascar" , Neil Cumberlidge, Kirstin S. Meyer
"A New Species Of Foza Reed & Cumberlidge, 2006, From Northern Madagascar" , Neil Cumberlidge, Kirstin S. Meyer
Journal Articles
No abstract provided.
Freshwater Crabs And The Biodiversity Crisis: Importance, Threats, Status, And Conservation Challenges, Neil Cumberlidge, Peter Kl Ng, Darren Cj Yeo, Celio Magalhães, Martha R. Campos, Fernando Alvarez, Tohru Naruse, Savel R. Daniels, Lara J. Esser, Felix Yk Attipoe, France-Lyse Clotilde-Ba, William Darwall, Anna Mcivor, Jonathan Em Baillie, Ben Collen, Mala Ram
Freshwater Crabs And The Biodiversity Crisis: Importance, Threats, Status, And Conservation Challenges, Neil Cumberlidge, Peter Kl Ng, Darren Cj Yeo, Celio Magalhães, Martha R. Campos, Fernando Alvarez, Tohru Naruse, Savel R. Daniels, Lara J. Esser, Felix Yk Attipoe, France-Lyse Clotilde-Ba, William Darwall, Anna Mcivor, Jonathan Em Baillie, Ben Collen, Mala Ram
Journal Articles
No abstract provided.