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Neuronal Glutamate Transporter Eaac1 Regulates Motor Activity And Anxiety In Mice, Kelsey Fleming
Neuronal Glutamate Transporter Eaac1 Regulates Motor Activity And Anxiety In Mice, Kelsey Fleming
Biological Sciences
Obsessive Compulsive disorder (OCD) is a neuropsychiatric disorder characterized by the onset of recurrent thoughts, anxiety, and repetitive motor behaviors. The molecular basis of OCD remains elusive, but recent meta-analysis and genome-wide association studies (GWAS) suggest the existence of a genetic association between polymorphisms in the gene coding for excitatory amino acid carrier 1 (EAAC1) and OCD. It is also known that the Cortico-Striatal-Thalamo-Cortical (CSTC) pathway shows patterned hyperactivity in patients with OCD. EAAC1 is the primary neuronal glutamate transporter in the brain and is abundantly expressed in the cortex and the striatum, two regions that are part of the …