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Long-Term Effects Of Estradiol Replacement In The Olfactory System, Britto P. Nathan, Michael Tonsor, Robert G. Struble
Long-Term Effects Of Estradiol Replacement In The Olfactory System, Britto P. Nathan, Michael Tonsor, Robert G. Struble
Britto P. Nathan
Olfactory dysfunction often precedes other clinical symptoms in chronic neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Estrogen deficiency and apoE genotype are known risk factors in these diseases and these factors also affect olfaction. Therefore we examined the effects of estradiol replacement following ovariectomy on expression of apoE and markers of cell proliferation, neuronal maturation, synaptogenesis and reactive gliosis in the primary olfactory pathway of wild-type (WT) and apoE knockout (KO) mice. Estradiol replacement increased apoE staining in the olfactory nerve and glomerular layers. Estradiol increased astrocyte density and olfactory epithelium (OE) thickness regardless of the genotype. In addition estradiol …
Long-Term Effects Of Estradiol Replacement In The Olfactory System, Britto P. Nathan, Michael Tonsor, Robert G. Struble
Long-Term Effects Of Estradiol Replacement In The Olfactory System, Britto P. Nathan, Michael Tonsor, Robert G. Struble
Faculty Research & Creative Activity
Olfactory dysfunction often precedes other clinical symptoms in chronic neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Estrogen deficiency and apoE genotype are known risk factors in these diseases and these factors also affect olfaction. Therefore we examined the effects of estradiol replacement following ovariectomy on expression of apoE and markers of cell proliferation, neuronal maturation, synaptogenesis and reactive gliosis in the primary olfactory pathway of wild-type (WT) and apoE knockout (KO) mice. Estradiol replacement increased apoE staining in the olfactory nerve and glomerular layers. Estradiol increased astrocyte density and olfactory epithelium (OE) thickness regardless of the genotype. In addition estradiol …
Long-Term Effects Of Estradiol Replacement In The Olfactory System, Britto Nathan, Michael Tonsor, Robert Struble
Long-Term Effects Of Estradiol Replacement In The Olfactory System, Britto Nathan, Michael Tonsor, Robert Struble
Faculty Research & Creative Activity
Olfactory dysfunction often precedes other clinical symptoms in chronic neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. Estrogen deficiency and apoE genotype are known risk factors in these diseases and these factors also affect olfaction. Therefore we examined the effects of estradiol replacement following ovariectomy on expression of apoE and markers of cell proliferation, neuronal maturation, synaptogenesis and reactive gliosis in the primary olfactory pathway of wild-type (WT) and apoE knockout (KO) mice. Estradiol replacement increased apoE staining in the olfactory nerve and glomerular layers. Estradiol increased astrocyte density and olfactory epithelium (OE) thickness regardless of the genotype. In addition estradiol …
Acute Responses To Estradiol Replacement In The Olfactory System Of Apoe-Deficient And Wild-Type Mice, Britto P. Nathan, Michael Tonsor, Robert G. Struble
Acute Responses To Estradiol Replacement In The Olfactory System Of Apoe-Deficient And Wild-Type Mice, Britto P. Nathan, Michael Tonsor, Robert G. Struble
Britto P. Nathan
Epidemiological studies suggest that estrogen therapy protects against clinical expression of chronic neurological diseases. These beneficial effects of estrogen therapy are highly modified by apolipoprotein E (apoE) through an unknown mechanism. We examined the short-term effects of estradiol replacement in ovariectomized mice on apoE expression and markers for cell proliferation, reactive gliosis, neuronal maturation, and synaptogenesis in the primary olfactory pathway of wild-type (WT) and apoE knockout (KO) mice. Three days of estradiol replacement increased apoE expression in the olfactory nerve and in the glomerular layer. Estradiol treatment also increased cell proliferation, total cell numbers, number of mature neurons in …
Acute Responses To Estradiol Replacement In The Olfactory System Of Apoe-Deficient And Wild-Type Mice, Britto P. Nathan, Michael Tonsor, Robert G. Struble
Acute Responses To Estradiol Replacement In The Olfactory System Of Apoe-Deficient And Wild-Type Mice, Britto P. Nathan, Michael Tonsor, Robert G. Struble
Faculty Research & Creative Activity
Epidemiological studies suggest that estrogen therapy protects against clinical expression of chronic neurological diseases. These beneficial effects of estrogen therapy are highly modified by apolipoprotein E (apoE) through an unknown mechanism. We examined the short-term effects of estradiol replacement in ovariectomized mice on apoE expression and markers for cell proliferation, reactive gliosis, neuronal maturation, and synaptogenesis in the primary olfactory pathway of wild-type (WT) and apoE knockout (KO) mice. Three days of estradiol replacement increased apoE expression in the olfactory nerve and in the glomerular layer. Estradiol treatment also increased cell proliferation, total cell numbers, number of mature neurons in …
Acute Responses To Estradiol Replacement In The Olfactory System Of Apoe-Deficient And Wild-Type Mice, Britto Nathan, Michael Tonsor, Robert Struble
Acute Responses To Estradiol Replacement In The Olfactory System Of Apoe-Deficient And Wild-Type Mice, Britto Nathan, Michael Tonsor, Robert Struble
Faculty Research & Creative Activity
Epidemiological studies suggest that estrogen therapy protects against clinical expression of chronic neurological diseases. These beneficial effects of estrogen therapy are highly modified by apolipoprotein E (apoE) through an unknown mechanism. We examined the short-term effects of estradiol replacement in ovariectomized mice on apoE expression and markers for cell proliferation, reactive gliosis, neuronal maturation, and synaptogenesis in the primary olfactory pathway of wild-type (WT) and apoE knockout (KO) mice. Three days of estradiol replacement increased apoE expression in the olfactory nerve and in the glomerular layer. Estradiol treatment also increased cell proliferation, total cell numbers, number of mature neurons in …
Reconstitution Of The Olfactory Epithelium Following Injury In Apoe-Deficient Mice, Britto P. Nathan, Salina Gairhe, Ikemefuna Nwosu, Stephen Clark, Robert G. Struble
Reconstitution Of The Olfactory Epithelium Following Injury In Apoe-Deficient Mice, Britto P. Nathan, Salina Gairhe, Ikemefuna Nwosu, Stephen Clark, Robert G. Struble
Britto P. Nathan
ApoE, a protein component of lipoproteins, is extensively expressed in the primary olfactory pathway. Because apoE has been shown to play a vital role in nerve repair and remodeling, we hypothesized that apoE expression will increase in the injured olfactory epithelium (OE), and that apoE deficiency in apoE knockout (KO) mice will lead to delayed/incomplete reconstitution of the OE following injury. To directly test this hypothesis, we compared OE regeneration in wild-type (WT) and KO mice following injury induced by intranasal irrigation of Triton X-100. OE was collected at 0, 3, 7, 21, 42, and 56 days post lesion. The …
Reconstitution Of The Olfactory Epithelium Following Injury In Apoe-Deficient Mice, Britto P. Nathan, Salina Gairhe, Ikemefuna Nwosu, Stephen Clark, Robert G. Struble
Reconstitution Of The Olfactory Epithelium Following Injury In Apoe-Deficient Mice, Britto P. Nathan, Salina Gairhe, Ikemefuna Nwosu, Stephen Clark, Robert G. Struble
Faculty Research & Creative Activity
ApoE, a protein component of lipoproteins, is extensively expressed in the primary olfactory pathway. Because apoE has been shown to play a vital role in nerve repair and remodeling, we hypothesized that apoE expression will increase in the injured olfactory epithelium (OE), and that apoE deficiency in apoE knockout (KO) mice will lead to delayed/incomplete reconstitution of the OE following injury. To directly test this hypothesis, we compared OE regeneration in wild-type (WT) and KO mice following injury induced by intranasal irrigation of Triton X-100. OE was collected at 0, 3, 7, 21, 42, and 56 days post lesion. The …
Reconstitution Of The Olfactory Epithelium Following Injury In Apoe-Deficient Mice, Britto Nathan, Salina Gairhe, Ikemefuna Nwosu, Stephen Clark, Robert Struble
Reconstitution Of The Olfactory Epithelium Following Injury In Apoe-Deficient Mice, Britto Nathan, Salina Gairhe, Ikemefuna Nwosu, Stephen Clark, Robert Struble
Faculty Research & Creative Activity
ApoE, a protein component of lipoproteins, is extensively expressed in the primary olfactory pathway. Because apoE has been shown to play a vital role in nerve repair and remodeling, we hypothesized that apoE expression will increase in the injured olfactory epithelium (OE), and that apoE deficiency in apoE knockout (KO) mice will lead to delayed/incomplete reconstitution of the OE following injury. To directly test this hypothesis, we compared OE regeneration in wild-type (WT) and KO mice following injury induced by intranasal irrigation of Triton X-100. OE was collected at 0, 3, 7, 21, 42, and 56 days post lesion. The …
The Distribution Of Apolipoprotein E In Mouse Olfactory Epithelium, Britto P. Nathan, Sreenivas Nannapaneni, Salina Gairhe, Ikemefuna Nwosu, Robert G. Struble
The Distribution Of Apolipoprotein E In Mouse Olfactory Epithelium, Britto P. Nathan, Sreenivas Nannapaneni, Salina Gairhe, Ikemefuna Nwosu, Robert G. Struble
Britto P. Nathan
Previous studies from our laboratory suggest that apolipoprotein (apoE), a lipid transporting protein, facilitates olfactory nerve regeneration. We have shown that apoE is enriched in the olfactory nerve and around the glomeruli of the olfactory bulb (OB). The studies reported herein were undertaken to identify possible sources of apoE in the olfactory epithelium (OE). Immunoblotting results revealed apoE expression in the OE of wild-type (WT) mice, but not in apoE deficient/knockout (KO) mice. Immunohistochemical studies revealed that the perikarya and processes of sustentacular (Sus) cells expressed apoE-like immunoreactivity. Minimal neuronal apoE immunostaining was seen, although apoE was observed in the …
The Distribution Of Apolipoprotein E In Mouse Olfactory Epithelium, Britto P. Nathan, Sreenivas Nannapaneni, Salina Gairhe, Ikemefuna Nwosu, Robert G. Struble
The Distribution Of Apolipoprotein E In Mouse Olfactory Epithelium, Britto P. Nathan, Sreenivas Nannapaneni, Salina Gairhe, Ikemefuna Nwosu, Robert G. Struble
Faculty Research & Creative Activity
Previous studies from our laboratory suggest that apolipoprotein (apoE), a lipid transporting protein, facilitates olfactory nerve regeneration. We have shown that apoE is enriched in the olfactory nerve and around the glomeruli of the olfactory bulb (OB). The studies reported herein were undertaken to identify possible sources of apoE in the olfactory epithelium (OE). Immunoblotting results revealed apoE expression in the OE of wild-type (WT) mice, but not in apoE deficient/knockout (KO) mice. Immunohistochemical studies revealed that the perikarya and processes of sustentacular (Sus) cells expressed apoE-like immunoreactivity. Minimal neuronal apoE immunostaining was seen, although apoE was observed in the …
The Distribution Of Apolipoprotein E In Mouse Olfactory Epithelium, Britto Nathan, Sreenivas Nannapaneni, Salina Gairhe, Ikemefuna Nwosu, Robert Struble
The Distribution Of Apolipoprotein E In Mouse Olfactory Epithelium, Britto Nathan, Sreenivas Nannapaneni, Salina Gairhe, Ikemefuna Nwosu, Robert Struble
Faculty Research & Creative Activity
Previous studies from our laboratory suggest that apolipoprotein (apoE), a lipid transporting protein, facilitates olfactory nerve regeneration. We have shown that apoE is enriched in the olfactory nerve and around the glomeruli of the olfactory bulb (OB). The studies reported herein were undertaken to identify possible sources of apoE in the olfactory epithelium (OE). Immunoblotting results revealed apoE expression in the OE of wild-type (WT) mice, but not in apoE deficient/knockout (KO) mice. Immunohistochemical studies revealed that the perikarya and processes of sustentacular (Sus) cells expressed apoE-like immunoreactivity. Minimal neuronal apoE immunostaining was seen, although apoE was observed in the …