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Full-Text Articles in Biology
Identification Of Disufide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1, Morgan E. Roberts, Jacquelyn P. Crail, Megan M. Laffoon, William G. Fernandez, Michael A. Menze, Mary E. Konkle
Identification Of Disufide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1, Morgan E. Roberts, Jacquelyn P. Crail, Megan M. Laffoon, William G. Fernandez, Michael A. Menze, Mary E. Konkle
Faculty Research & Creative Activity
MitoNEET is a protein that was identified as a drug target for diabetes, but its cellular function as well as its role in diabetes remains elusive. Protein pull-down experiments identified glutamate dehydrogenase 1 (GDH1) as a potential binding partner. GDH1 is a key metabolic enzyme with emerging roles in insulin regulation. MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator. Proteomic analysis identified the specific cysteine residues that participate in the disulfide bond. This is the first report that effectively links mitoNEET to activation of the insulin regulator GDH1.
Identification Of Disulfide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1, Morgan E. Roberts, Jacquelyn P. Crail, Megan M. Laffoon, William G. Fernandez, Michael A. Menze, Mary E. Konkle
Identification Of Disulfide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1, Morgan E. Roberts, Jacquelyn P. Crail, Megan M. Laffoon, William G. Fernandez, Michael A. Menze, Mary E. Konkle
Faculty Research & Creative Activity
MitoNEET is a protein that was identified as a drug target for diabetes, but its cellular function as well as its role in diabetes remains elusive. Protein pull-down experiments identified glutamate dehydrogenase 1 (GDH1) as a potential binding partner. GDH1 is a key metabolic enzyme with emerging roles in insulin regulation. MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator. Proteomic analysis identified the specific cysteine residues that participate in the disulfide bond. This is the first report that effectively links mitoNEET to activation of the insulin regulator GDH1.
A Sketch-Based Language For Representing Uncertainty In The Locations Of Origin Of Herbarium Specimens, Barry J. Kronenfeld, Andrew Weeks
A Sketch-Based Language For Representing Uncertainty In The Locations Of Origin Of Herbarium Specimens, Barry J. Kronenfeld, Andrew Weeks
Barry J. Kronenfeld
Uncertainty fields have been suggested as an appropriate model for retrospective georeferencing of herbarium specimens. Previous work has focused only on automated data capture methods, but techniques for manual data specification may be able to harness human spatial cognition skills to quickly interpret complex spatial propositions. This paper develops a formal modeling language by which location uncertainty fields can be derived from manually sketched features. The language consists of low-level specification of critical probability isolines from which a surface can be uniquely derived, and high-level specification of features and predicates from which low-level isolines can be derived. In a case …
A Sketch-Based Language For Representing Uncertainty In The Locations Of Origin Of Herbarium Specimens, Barry J. Kronenfeld, Andrew Weeks
A Sketch-Based Language For Representing Uncertainty In The Locations Of Origin Of Herbarium Specimens, Barry J. Kronenfeld, Andrew Weeks
Faculty Research and Creative Activity
Uncertainty fields have been suggested as an appropriate model for retrospective georeferencing of herbarium specimens. Previous work has focused only on automated data capture methods, but techniques for manual data specification may be able to harness human spatial cognition skills to quickly interpret complex spatial propositions. This paper develops a formal modeling language by which location uncertainty fields can be derived from manually sketched features. The language consists of low-level specification of critical probability isolines from which a surface can be uniquely derived, and high-level specification of features and predicates from which low-level isolines can be derived. In a case …
A Sketch-Based Language For Representing Uncertainty In The Locations Of Origin Of Herbarium Specimens, Barry Kronenfeld, Andrew Weeks
A Sketch-Based Language For Representing Uncertainty In The Locations Of Origin Of Herbarium Specimens, Barry Kronenfeld, Andrew Weeks
Faculty Research and Creative Activity
Uncertainty fields have been suggested as an appropriate model for retrospective georeferencing of herbarium specimens. Previous work has focused only on automated data capture methods, but techniques for manual data specification may be able to harness human spatial cognition skills to quickly interpret complex spatial propositions. This paper develops a formal modeling language by which location uncertainty fields can be derived from manually sketched features. The language consists of low-level specification of critical probability isolines from which a surface can be uniquely derived, and high-level specification of features and predicates from which low-level isolines can be derived. In a case …