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Analysis Of Sry Duplications On The Rattus Norvegicus Y-Chromosome, Jeremy W. Prokop, Adam C. Underwood, Monte E. Turner, Nic Miller, Dawn Pietzrak, Sarah Scott, Chris Smith, Amy Milsted
Analysis Of Sry Duplications On The Rattus Norvegicus Y-Chromosome, Jeremy W. Prokop, Adam C. Underwood, Monte E. Turner, Nic Miller, Dawn Pietzrak, Sarah Scott, Chris Smith, Amy Milsted
Amy Milsted
Background: Gene copy number variation plays a large role in the evolution of genomes. In Rattus norvegicus and other rodent species, the Y-chromosome has accumulated multiple copies of Sry loci. These copy number variations have been previously linked with changes in phenotype of animal models such as the spontaneously hypertensive rat (SHR). This study characterizes the Y-chromosome in the Sry region of Rattus norvegicus, while addressing functional variations seen in the Sry protein products. Results: Eleven Sry loci have been identified in the SHR with one (nonHMG Sry) containing a frame shift mutation. The nonHMGSry is found and conserved in …