Bioinformatics Commons^™

Optimizing Outpatient Radiation Oncology Consult Workflow By Using Time-Driven Activity-Based Costing: Efficiency And Financial Impacts, Julius Weng, Shane Mesko, Gregory Chronowski, Percy Lee, Seungtaek Choi, Prajnan Das, Albert C Koong, Katy French, Thomas Aloia, Richie Ehlers, Dorothy Elrod-Joplin, Ashley Kerr, Regina Smith, Wendi Martinez, Elizabeth Bloom, Shalin J Shah, Matthew S Ning, Zhongxing Liao, Joseph Herman, Shalini Moningi, Amy C Moreno, Quynh-Nhu Nguyen

Student and Faculty Publications

PURPOSE: Clinical efficiency is a key component of value-based health care. Our objective here was to identify workflow inefficiencies by using time-driven activity-based costing (TDABC) and evaluate the implementation of a new clinical workflow in high-volume outpatient radiation oncology clinics.

METHODS: Our quality improvement study was conducted with the Departments of GI, Genitourinary (GU), and Thoracic Radiation Oncology at a large academic cancer center and four community network sites. TDABC was used to create process maps and optimize workflow for outpatient consults. Patient encounter metrics were captured with a real-time status function in the electronic medical record. Time metrics were …

Vibes: A Workflow For Annotating And Visualizing Viral Sequences Integrated Into Bacterial Genomes, Conner J. Copeland

Graduate Student Theses, Dissertations, & Professional Papers

Bacteriophages are viruses that infect bacteria. Many bacteriophages integrate their genomes into the bacterial chromosome and become prophages. Prophages may substantially burden or benefit host bacteria fitness, acting in some cases as parasites and in others as mutualists, and have been demonstrated to increase host virulence. The increasing ease of bacterial genome se- quencing provides an opportunity to deeply explore prophage prevalence and insertion sites. Here we present VIBES, a workflow intended to automate prophage annotation in complete bacterial genome sequences. VIBES provides additional context to prophage annotations by annotating bac- terial genes and viral proteins in user-provided bacterial and …

Predicting Disease-Related Genes Using Integrated Biomedical Networks, Jiajie Peng, Kun Bai, Xuequn Shang, Guohua Wang, Hansheng Xue, Shuilin Jin, Liang Cheng, Yadong Wang, Jin Chen

Institute for Biomedical Informatics Faculty Publications

Background: Identifying the genes associated to human diseases is crucial for disease diagnosis and drug design. Computational approaches, esp. the network-based approaches, have been recently developed to identify disease-related genes effectively from the existing biomedical networks. Meanwhile, the advance in biotechnology enables researchers to produce multi-omics data, enriching our understanding on human diseases, and revealing the complex relationships between genes and diseases. However, none of the existing computational approaches is able to integrate the huge amount of omics data into a weighted integrated network and utilize it to enhance disease related gene discovery.

Results: We propose a new network-based disease …

Cloud Based Scientific Workflow For Nmr Data Analysis, Ashwin Manjunatha, Paul E. Anderson, Satya S. Sahoo, Ajith Harshana Ranabahu, Michael L. Raymer, Amit P. Sheth

Kno.e.sis Publications

This work presents a service oriented scientific workflow approach to NMR-based metabolomics data analysis. We demonstrate the effectiveness of this approach by implementing several common spectral processing techniques in the cloud using a parallel map-reduce framework, Hadoop.

Openws-Transaction: Enabling Reliable Web Service Transactions, Ivan Vasquez, John A. Miller, Kunal Verma, Amit P. Sheth

Kno.e.sis Publications

OpenWS-Transaction is an open source middleware that enables Web services to participate in a distributed transaction as prescribed by the WS-Coordination and WS-Transaction set of specifications. Central to the framework are the Coordinator and Participant entities, which can be integrated into existing services by introducing minimal changes to application code. OpenWS-Transaction allows transaction members to recover their original state in case of operational failure by leveraging techniques in logical logging and recovery at the application level. Depending on transaction style, system recovery may involve restoring key application variables and replaying uncommitted database activity. Transactions are assumed to be defined in …

The Carnot Heterogeneous Database Project: Implemented Applications, Munindar Singh, Phil Cannata, Michael N. Huhns, Nigel Jacobs, Tomasz Ksiezyk, Kayliang Ong, Amit P. Sheth, Christine Tomlinson, Darrell Woelk

Kno.e.sis Publications

The Carnot project was an ambitious research project in heterogeneous databases. It integrated a variety of techniques to address a wide range of problems in achieving interoperation in heterogeneous environments. Here we describe some of the major implemented applications of this project. These applications concern(a) accessing a legacy scientific database, (b) automating a workflow involving legacy systems, (c) cleaning data, and (d) retrieving semantically appropriate information from structured databases in response to text queries. These applications support scientific decision support, business process management, data integrity enhancement, and analytical decision support, respectively. They demonstrate Carnot‘s capabilities for (a) heterogeneous query processing, …

Specifying And Enforcing Intertask Dependencies, Paul Attie, Munindar Singh, Amit P. Sheth, Marek Rusinkiewicz

Kno.e.sis Publications

Extensions of the traditional atomic transaction model are needed to support the development of multi-system applications or workflows that access heterogeneous databases and legacy application systems. Most extended transaction models use conditions involving events or dependencies between transactions. Intertask dependencies can serve as a uniform framework for defining extended transaction models. In this paper we introduce event attributes needed to determine whether a dependency is enforceable and to properly schedule events in extended transaction models. Using these attributes and a formalization of a dependency into the temporal logic CTL, we can automatically synthesize an automaton that captures the computations that …

On Transactional Workflows, Amit P. Sheth, Marek Rusinkiewicz

Kno.e.sis Publications

The basic transaction model has evolved over time to incorporate more complex transactions structures and to take the advantage of semantics of higher-level operations that cannot be seen at the level of page reads and writes. Well known examples of such extended transaction models include nested and multi-level transactions. A number of relaxed transaction models have been defined in the last several years that permit a controlled relaxation of the transaction isolation and atomicity to better match the requirements of various database applications. Correctness criteria other than global serializability have also been proposed. Several examples of extended/relaxed transaction models are …

Executing Multidatabase Transactions, Mansoor Ansari, Marek Rusinkiewicz, Linda Ness, Amit P. Sheth

Kno.e.sis Publications

In a multidatabase environment, the traditional transaction model has been found to be too restrictive. Therefore, several extended transaction models have been proposed in which some of the requirements of transaction, such as isolation or atomicity, are optional. The authors describe one of such extensions, the flexible transaction model and discuss the scheduling of transactions involving multiple autonomous database systems managed by heterogeneous DBMS.

The scheduling algorithm for flexible transactions is implemented using L.0, a logically parallel language which provides a framework for concisely specifying the multidatabase transactions and for scheduling them. The key aspects of a flexible transaction specification, …