Open Access. Powered by Scholars. Published by Universities.®
Other Biochemistry, Biophysics, and Structural Biology Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Other Biochemistry, Biophysics, and Structural Biology
Dom Control Of Mercury Methylation In The Water Column Of A Meromictic Lake, Madalyn Bozinski
Dom Control Of Mercury Methylation In The Water Column Of A Meromictic Lake, Madalyn Bozinski
Honors Capstone Projects - All
The trophic transfer and bioaccumulation of methyl mercury (MeHg) in aquatic ecosystems is a substantial concern, resulting in fish consumption advisories worldwide. Aquatic ecosystems have been identified as the critical environments that breed production of MeHg and low levels of initial accumulation in biota. MeHg production is a microbially-mediated process, occurring primarily at the transition between oxic and anoxic environments. This research aimed to assess the extent to which dissolved organic matter (DOM) affects methylation of mercury in the oligotrophic meromictic lake, Green Lake, in Fayetteville, NY and the warm monomictic lake, Seneca Lake, in Geneva, NY. General physical parameters …
Does Vibrational Loading Modulate The Effects Of Radiotherapy On Growing Bone?, Samantha Hay
Does Vibrational Loading Modulate The Effects Of Radiotherapy On Growing Bone?, Samantha Hay
Honors Capstone Projects - All
Radiotherapy is an important part of cancer therapy, used in addition to surgery for treatment of patients with soft tissue sarcomas, and alternatively for treatment of patients with Ewing sarcoma of bone. Treating pediatric extremity tumors with radiotherapy has been shown to have harmful effects on the epiphyseal plate, resulting in permanent limb shortening and deformity when bone growth centers are exposed to radiation. Mechanical signals, specifically low-magnitude high-frequency vibrations (LMHFV), have been shown to be non-invasive and non-pharmacological growth factors in bone that have the potential to serve as a safe treatment for a number of clinical conditions. Thus, …
Recombinant Expression And Purification Of Human Intrinsic Factor (If) And Mutants K159d And Q201a Designed To Interfere With Cubilin Receptor Binding, Soreen Cyphers
Honors Capstone Projects - All
Although both the α- and β-domains of intrinsic factor (IF) have been previously expressed, the full crystal structure of the protein has yet to be reported. The purpose of this research is to (1) express IF in order to obtain a complete crystal structure and (2) utilize a mutant form of IF in order to orally deliver rotavirus to the ileum.The first goal of this research is to express IF in the yeast Pichia pastoris. The second goal is to express a K159D IF mutant protein. K159 of IF plays a role in salt bridge formation between IF and …