Open Access. Powered by Scholars. Published by Universities.®
Other Biochemistry, Biophysics, and Structural Biology Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Other Biochemistry, Biophysics, and Structural Biology
Biophysical Exploration Of Conformational Environments In Zymogen Prothrombin And Blood Coagulant Thrombin., Ramya Billur
Biophysical Exploration Of Conformational Environments In Zymogen Prothrombin And Blood Coagulant Thrombin., Ramya Billur
Electronic Theses and Dissertations
The serine protease thrombin plays important roles in coagulation, anticoagulation, and platelet activation. Thrombin is initially expressed as the inactive zymogen prothrombin (ProT). The final cleaved and activated form of thrombin has mature anion binding exosites (ABEs) and several regulatory loops. Engagement with these exosites helps define the fate of thrombin as a procoagulant or an anticoagulant. Researchers previously reported that zymogen ProT may already bind exosite ligands. Little is known about conformational changes associated with ProT maturation, resultant ligand binding affinities, individual ligand-protein contacts, and long-range communication between thrombin exosites. Protease Activated Receptors (PARs) play critical roles in controlling …