Molecular Biology Commons^™

The N-Terminus Of The Saccharomyces Cerevisiae G Protein-Coupled Receptor Ste2p: Formation Of Dimer Interfaces And Negative Regulation, Mohammad Seraj Uddin

Doctoral Dissertations

G protein-coupled receptors (GPCRs), the largest family of membrane proteins on the cell surface, play essential roles in signal transduction in all eukaryotic organisms. These proteins are responsible for sensing and detecting a wide range of extracellular stimuli and translating them to intracellular responses. This signaling requires a tight control for receptor activation without which abnormal signal leads to diseases. In fact, malfunctions of these receptors are associated with numerous pathological conditions and currently an estimated 40-50% of therapeutic drugs are designed to target these receptors suggesting that further increases in understanding of GPCRs and the signaling pathways they initiate …