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Full-Text Articles in Molecular Biology
The Expression Patterns Of Minor Fibrillar Collagens During Development In Zebrafish, Ming Fang, Jason S. Adams, B. Lane Memahhan, Raquel J. Brown, Julia Oxford
The Expression Patterns Of Minor Fibrillar Collagens During Development In Zebrafish, Ming Fang, Jason S. Adams, B. Lane Memahhan, Raquel J. Brown, Julia Oxford
Biomolecular Research Center Publications and Presentations
Minor fibrillar collagens are recognized as the organizers and nucleators during collagen fibrillogenesis but likely serve additional functions. The minor fibrillar collagens include collagens type V and type XI. Mutations of collagen type V and XI can cause Ehlers Danlos, Stickler's, and Marshall's syndromes in human. We have characterized the spatiotemporal expression patterns of Col11a1, Col11a2, Col5a1 as well as Col5a3 in zebrafish embryos by in situ hybridization. Col5a1 is expressed in developing somites, neural crest, the head mesenchyme, developing cranial cartilage, pharyngeal arches and vertebrae. Col5a3 is detected in the notochord, mesenchyme cells in the eyes and lens. Both …