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Development Of Novel Prolactin And Growth Hormone Receptor Agonists And Antagonists, John Langenheim
Development Of Novel Prolactin And Growth Hormone Receptor Agonists And Antagonists, John Langenheim
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Potential indications for human prolactin (hPRL) and human growth hormone (hGH) are the support and sustainment of lactation and the enhancement or reconstitution of the immune system when under dysregulation. A prolactin receptor (PRLR) antagonist, hPRL-G129R (G129R), and a PRLR and growth hormone receptor (GHR) antagonist, hGH-G120R (G120R), have been developed which may be useful for the treatment of breast cancer since PRLR is elevated in a majority of human breast tumors and makes cancer cells highly sensitive to the mitogenic and anti-apoptotic activity of hPRL and hGH.
As a single agent, G129R is more cytostatic than cytotoxic to human …