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Full-Text Articles in Molecular Biology
Role Of Retinoids In The Regulation Of Hepatic Glucose And Lipid Metabolism, Rui Li
Role Of Retinoids In The Regulation Of Hepatic Glucose And Lipid Metabolism, Rui Li
Doctoral Dissertations
The liver plays an important role in controlling glucose and lipid homeostasis. Metabolic abnormalities such as obesity and type 2 diabetes are often associated with profound changes in the expression of genes involved in hepatic glucose and lipid metabolism. Dietary nutrients provide us with macronutrients for energy and micronutrients for maintenance of general health. However, the effects of individual micronutrients on the development of metabolic diseases are unknown. Sterol regulatory element binding protein-1c (SREBP-1c) is the master regulator of fatty acid synthesis, and glucokinase (GK) is the key enzyme in glucose metabolism. Based on the preliminary results from our laboratory …