Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Bacterial Infections and Mycoses (1)
- Behavioral Neurobiology (1)
- Biological Phenomena, Cell Phenomena, and Immunity (1)
- Cell Biology (1)
- Cell and Developmental Biology (1)
-
- Disease Modeling (1)
- Diseases (1)
- Immunology and Infectious Disease (1)
- Immunology of Infectious Disease (1)
- Laboratory and Basic Science Research (1)
- Medical Cell Biology (1)
- Medical Molecular Biology (1)
- Medical Sciences (1)
- Medicine and Health Sciences (1)
- Microbiology (1)
- Molecular and Cellular Neuroscience (1)
- Neuroscience and Neurobiology (1)
- Pathogenic Microbiology (1)
- Institution
Articles 1 - 2 of 2
Full-Text Articles in Molecular Biology
All The Rage: Assessing The Age/Rage Signaling Pathway’S Effects On Healthspan And The Physiological Processes Of Aging, Brandon Ashmore
All The Rage: Assessing The Age/Rage Signaling Pathway’S Effects On Healthspan And The Physiological Processes Of Aging, Brandon Ashmore
Honors Theses
Advanced glycation end products (AGEs) are protein, lipid, or nucleotide molecules that have been combined with sugars through nonenzymatic, irreversible glycation and oxidation reactions. Their accumulation in the body has been associated with the natural aging process and a wide range of pathologies, including chronic inflammation, sustained oxidative stress, diabetes, neurodegenerative diseases, atherosclerosis, and cancer. Their interaction with the receptor for advanced glycation end products (RAGE) has been linked to several proinflammatory signaling pathways associated with neurotoxicity and vascular lesions. While some research has been done on the possible health benefits of RAGE inhibition to extend lifespan, our study hopes …
Immunomodulatory Effects Of Resolvin D2 In A Model Of Infection, Prem Yugandhar Kadiyam Sundarasivarao
Immunomodulatory Effects Of Resolvin D2 In A Model Of Infection, Prem Yugandhar Kadiyam Sundarasivarao
Graduate School of Biomedical Sciences Theses and Dissertations
Dysregulated hyperinflammatory host immune response to underlying bacterial infections is a characteristic of sepsis. In sepsis, bacteria often trigger abnormal hyperinflammatory responses which can cause multiple organ failure and if sustained can lead to an immunosuppressive phase where the host is susceptible to secondary infections caused by opportunistic bacteria like Pseudomonas aeruginosa (P. aeruginosa). In our studies, we used a 2-hit model of cecal ligation and puncture (CLP) followed by P. aeruginosa secondary lung infection to investigate cellular and molecular mechanisms in the beneficial action of resolvin D2 (RvD2). Resolvins of the D-series are a group of fatty acids known …