Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Biochemistry (1)
- Biological Engineering (1)
- Biomechanics and Biotransport (1)
- Biomedical Engineering and Bioengineering (1)
- Cell Biology (1)
-
- Cell and Developmental Biology (1)
- Chemicals and Drugs (1)
- Disease Modeling (1)
- Diseases (1)
- Engineering (1)
- Immunology and Infectious Disease (1)
- Immunotherapy (1)
- Laboratory and Basic Science Research (1)
- Lipids (1)
- Medicine and Health Sciences (1)
- Molecular, Cellular, and Tissue Engineering (1)
- Other Biomedical Engineering and Bioengineering (1)
- Pathological Conditions, Signs and Symptoms (1)
- Pharmaceutical Preparations (1)
- Respiratory Tract Diseases (1)
Articles 1 - 2 of 2
Full-Text Articles in Molecular Biology
The Impact Of Aging And Mechanical Injury On Alveolar Epithelial And Macrophage Responses In Acute Lung Injury And Inflammation, Michael S. Valentine
The Impact Of Aging And Mechanical Injury On Alveolar Epithelial And Macrophage Responses In Acute Lung Injury And Inflammation, Michael S. Valentine
Theses and Dissertations
Patients with severe lung pathologies, such as Acute Respiratory Distress Syndrome (ARDS), often require mechanical ventilation as a clinical intervention; however, this procedure frequently exacerbates the original pulmonary issue and produces an exaggerated inflammatory response that potentially leads to sepsis, multisystem organ failure, and mortality. This acute lung injury (ALI) condition has been termed Ventilator-Induced Lung Injury (VILI). Alveolar overdistension, cyclic atelectasis, and biotrauma are the primary injury mechanisms in VILI that lead to the loss of alveolar barrier integrity and pulmonary inflammation. Stress and strains during mechanical ventilation are believed to initiate alveolar epithelial mechanotransduction signaling mechanisms that contribute …
The Interaction Between Ceramide-1-Phosphate And Group Iva Cytosolic Phospholipase A2 And Its Role In Wound Healing, Patrick Macknight
The Interaction Between Ceramide-1-Phosphate And Group Iva Cytosolic Phospholipase A2 And Its Role In Wound Healing, Patrick Macknight
Theses and Dissertations
The sphingolipid, ceramide-1-phosphate (C1P), directly binds and activates Group IVA cytosolic phospholipase A2 (cPLA2a) to generate eicosanoids. Due to the role of eicosanoids in wound healing, we choose to use our novel genetic mouse model expressing cPLA2a with an ablated C1P interaction site (KI) to examine the cPLA2a/C1P interaction in wound healing. Wound closure rate was not affected, but wound maturation was dramatically enhanced by loss of the C1P/cPLA2α interaction based on the following findings. Wounds in KI mice displayed: i) increased infiltration of dermal fibroblasts into the wound environment; ii …