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Effect Of Osteoactivin And Bone Morphogenetic Protein-2 On Soft Tissue In Rat Spinal Fusion Model, Andrew Ohliger
Effect Of Osteoactivin And Bone Morphogenetic Protein-2 On Soft Tissue In Rat Spinal Fusion Model, Andrew Ohliger
Williams Honors College, Honors Research Projects
Osteoinductive therapeutic strategies are essential for the bone healing process and are applicable in multiple orthopaedic procedures. The novel protein Osteoactivin (OA) has proven to stimulate osteoblast differentiation and function in vitro and bone regeneration in vivo in the rat model. More recently, OA has shown significant bone regeneration ability in sheep. The goal of this study is the comparison of osteoactivin with bone morphogenetic protein-2 (BMP-2) in the rat spinal fusion model.