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Full-Text Articles in Molecular Biology
The Impact Of Microbial Experience On The Murine Innate Immune Response, Cody Thomas Morrison
The Impact Of Microbial Experience On The Murine Innate Immune Response, Cody Thomas Morrison
Masters Theses
The hygiene hypothesis predicts that certain environmental factors shape overall immune system function in animals and humans. While current specific pathogen free (SPF) mouse models are invaluable for studying the immune system, they have limitations for comparison with humans who have microbial exposures throughout their lifetimes. Several studies have shown that the composition of the immune system of SPF mice more closely resembles that of newborns, whereas the immune system from mice exposed to microbial pathogens more closely reflect adult immunity. In this study we have established a model using traditional SPF mice (“clean mice”) and SPF mice that were …